TY - JOUR
T1 - Simulation of stochastic micropopulation models-IV. Snappers
T2 - Model implementation for genetic traits
AU - Goay, Michael S.C.
AU - Prasad, Badri
AU - Gilbertson, David
AU - Altmann, Michael
AU - Mc Gue, Matt
AU - Gatewood, Lael C
AU - Rich, Stephen S.
PY - 1995/11
Y1 - 1995/11
N2 - The current paper concerning stochastic micropopulation simulations describes SNAPPERS, which serves as a framework for simulation models of the genetic transmission of disease. The versions described are implemented using the simulation shell, SUMMERS, which includes the generic commonalities of several micropopulation models. Population members in SNAPPERS move through states related to the individual's status relative to the genotype (phenotype). Features of the model include one or two major loci, polygenic and common familial contribution to the phenotype, assortative mating, and flexibility in defining gene action. The user can select from multiple ascertainment strategies for analysis of simulated families.
AB - The current paper concerning stochastic micropopulation simulations describes SNAPPERS, which serves as a framework for simulation models of the genetic transmission of disease. The versions described are implemented using the simulation shell, SUMMERS, which includes the generic commonalities of several micropopulation models. Population members in SNAPPERS move through states related to the individual's status relative to the genotype (phenotype). Features of the model include one or two major loci, polygenic and common familial contribution to the phenotype, assortative mating, and flexibility in defining gene action. The user can select from multiple ascertainment strategies for analysis of simulated families.
KW - Genetic models
KW - Micropopulation model
KW - Monte Carlo techniques
KW - Stochastic simulation Genetic disease
UR - http://www.scopus.com/inward/record.url?scp=0028882567&partnerID=8YFLogxK
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U2 - 10.1016/0010-4825(95)00033-3
DO - 10.1016/0010-4825(95)00033-3
M3 - Article
C2 - 8665797
AN - SCOPUS:0028882567
SN - 0010-4825
VL - 25
SP - 519
EP - 531
JO - Computers in Biology and Medicine
JF - Computers in Biology and Medicine
IS - 6
ER -
