Simple synthesis of superparamagnetic magnetite nanoparticles as highly efficient contrast agent

Deepak K. Jha, Mohammad Shameem, Anant B. Patel, Aleksander Kostka, Paul Schneider, Andreas Erbe, P. Deb

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


Magnetite nanoparticles have been prepared by one-pot thermal decomposition process using iron (III) acetylacetonate in stearic acid in ambient environment. In this process, stearic acid acts as solvent as well as capping agent for the particles. These as-prepared hydrophobic magnetite nanoparticles have been converted into a hydrophilic form using tetramethylammonium hydroxide. This controlled surface functionalization approach limits microstructural and phase alteration due to the ligand exchange. A detailed investigation was carried out on the microstructural characteristics of these nanoparticles with the aid of X-ray diffraction, infrared spectroscopy, XPS and transmission electron microscopy. The hydrophilic superparamagnetic magnetite particles posses extraordinary transverse relaxivity and contrast property, making them potential T2 contrast agent in clinical magnetic resonance imaging.

Original languageEnglish (US)
Pages (from-to)186-189
Number of pages4
JournalMaterials Letters
StatePublished - 2013

Bibliographical note

Funding Information:
This work was financially supported by the Dept. of Biotechnology (DBT), Govt. of India ; grant no BT/ PR10874/ NNT/ 28/ 136/ 2008 . PD would like to acknowledge Max Planck India Fellowship for support. PS acknowledges support from Salzgitter Mannesmann Forschung GmbH in the frame of the IMPRS-SurMat. All MRI measurements were carried out at the NMR Micro imaging and Spectroscopy Facility, CCMB, Hyderabad, India.


  • Colloidal processing
  • MRI contrast agent
  • Superparamagnetic
  • XPS


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