Simple synthesis of superparamagnetic magnetite nanoparticles as highly efficient contrast agent

Deepak K. Jha; Mohammad Shameem; Anant B. Patel; Aleksander Kostka; Paul Schneider; Andreas Erbe; P. Deb

doi:10.1016/j.matlet.2012.12.096

Simple synthesis of superparamagnetic magnetite nanoparticles as highly efficient contrast agent

Deepak K. Jha, Mohammad Shameem, Anant B. Patel, Aleksander Kostka, Paul Schneider, Andreas Erbe, P. Deb

Biochemistry, Molecular Biology, and Biophysics (CBS)

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Magnetite nanoparticles have been prepared by one-pot thermal decomposition process using iron (III) acetylacetonate in stearic acid in ambient environment. In this process, stearic acid acts as solvent as well as capping agent for the particles. These as-prepared hydrophobic magnetite nanoparticles have been converted into a hydrophilic form using tetramethylammonium hydroxide. This controlled surface functionalization approach limits microstructural and phase alteration due to the ligand exchange. A detailed investigation was carried out on the microstructural characteristics of these nanoparticles with the aid of X-ray diffraction, infrared spectroscopy, XPS and transmission electron microscopy. The hydrophilic superparamagnetic magnetite particles posses extraordinary transverse relaxivity and contrast property, making them potential T₂ contrast agent in clinical magnetic resonance imaging.

Original language	English (US)
Pages (from-to)	186-189
Number of pages	4
Journal	Materials Letters
Volume	95
DOIs	https://doi.org/10.1016/j.matlet.2012.12.096
State	Published - 2013

Bibliographical note

Funding Information:
This work was financially supported by the Dept. of Biotechnology (DBT), Govt. of India ; grant no BT/ PR10874/ NNT/ 28/ 136/ 2008 . PD would like to acknowledge Max Planck India Fellowship for support. PS acknowledges support from Salzgitter Mannesmann Forschung GmbH in the frame of the IMPRS-SurMat. All MRI measurements were carried out at the NMR Micro imaging and Spectroscopy Facility, CCMB, Hyderabad, India.

Keywords

Colloidal processing
MRI contrast agent
Superparamagnetic
XPS

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10.1016/j.matlet.2012.12.096

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abstract = "Magnetite nanoparticles have been prepared by one-pot thermal decomposition process using iron (III) acetylacetonate in stearic acid in ambient environment. In this process, stearic acid acts as solvent as well as capping agent for the particles. These as-prepared hydrophobic magnetite nanoparticles have been converted into a hydrophilic form using tetramethylammonium hydroxide. This controlled surface functionalization approach limits microstructural and phase alteration due to the ligand exchange. A detailed investigation was carried out on the microstructural characteristics of these nanoparticles with the aid of X-ray diffraction, infrared spectroscopy, XPS and transmission electron microscopy. The hydrophilic superparamagnetic magnetite particles posses extraordinary transverse relaxivity and contrast property, making them potential T2 contrast agent in clinical magnetic resonance imaging.",

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author = "Jha, {Deepak K.} and Mohammad Shameem and Patel, {Anant B.} and Aleksander Kostka and Paul Schneider and Andreas Erbe and P. Deb",

note = "Funding Information: This work was financially supported by the Dept. of Biotechnology (DBT), Govt. of India ; grant no BT/ PR10874/ NNT/ 28/ 136/ 2008 . PD would like to acknowledge Max Planck India Fellowship for support. PS acknowledges support from Salzgitter Mannesmann Forschung GmbH in the frame of the IMPRS-SurMat. All MRI measurements were carried out at the NMR Micro imaging and Spectroscopy Facility, CCMB, Hyderabad, India. ",

year = "2013",

doi = "10.1016/j.matlet.2012.12.096",

language = "English (US)",

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pages = "186--189",

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AU - Jha, Deepak K.

AU - Shameem, Mohammad

AU - Patel, Anant B.

AU - Kostka, Aleksander

AU - Schneider, Paul

AU - Erbe, Andreas

AU - Deb, P.

N1 - Funding Information: This work was financially supported by the Dept. of Biotechnology (DBT), Govt. of India ; grant no BT/ PR10874/ NNT/ 28/ 136/ 2008 . PD would like to acknowledge Max Planck India Fellowship for support. PS acknowledges support from Salzgitter Mannesmann Forschung GmbH in the frame of the IMPRS-SurMat. All MRI measurements were carried out at the NMR Micro imaging and Spectroscopy Facility, CCMB, Hyderabad, India.

PY - 2013

Y1 - 2013

N2 - Magnetite nanoparticles have been prepared by one-pot thermal decomposition process using iron (III) acetylacetonate in stearic acid in ambient environment. In this process, stearic acid acts as solvent as well as capping agent for the particles. These as-prepared hydrophobic magnetite nanoparticles have been converted into a hydrophilic form using tetramethylammonium hydroxide. This controlled surface functionalization approach limits microstructural and phase alteration due to the ligand exchange. A detailed investigation was carried out on the microstructural characteristics of these nanoparticles with the aid of X-ray diffraction, infrared spectroscopy, XPS and transmission electron microscopy. The hydrophilic superparamagnetic magnetite particles posses extraordinary transverse relaxivity and contrast property, making them potential T2 contrast agent in clinical magnetic resonance imaging.

AB - Magnetite nanoparticles have been prepared by one-pot thermal decomposition process using iron (III) acetylacetonate in stearic acid in ambient environment. In this process, stearic acid acts as solvent as well as capping agent for the particles. These as-prepared hydrophobic magnetite nanoparticles have been converted into a hydrophilic form using tetramethylammonium hydroxide. This controlled surface functionalization approach limits microstructural and phase alteration due to the ligand exchange. A detailed investigation was carried out on the microstructural characteristics of these nanoparticles with the aid of X-ray diffraction, infrared spectroscopy, XPS and transmission electron microscopy. The hydrophilic superparamagnetic magnetite particles posses extraordinary transverse relaxivity and contrast property, making them potential T2 contrast agent in clinical magnetic resonance imaging.

KW - Colloidal processing

KW - MRI contrast agent

KW - Superparamagnetic

KW - XPS

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JO - Materials Letters

JF - Materials Letters

ER -

Simple synthesis of superparamagnetic magnetite nanoparticles as highly efficient contrast agent

Abstract

Bibliographical note

Keywords

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