Simple methods of rabbit hemolytic complement component assays

J. F. Lindorfer, J. S.C. Fong, R. A. Good

Research output: Contribution to journalArticle

Abstract

Simple methods for the titration of rabbit C1 and C5-9 have been developed which do not require purified complement components. The stable cellular intermediate, sheep erythrocyte - rabbit antibody - bovine complement C4 and C2 (SHEACBo42) is used for these assay methods with kinetic studies on the interaction between rabbit C1 and C5-9 with SHEACBo42 forming the basis for the methods. Furthermore, these assay methods have many applications for the evaluation of in vivo complement activation of both the classical and alternate pathways.

Original languageEnglish (US)
Pages (from-to)539-551
Number of pages13
JournalInternational Archives of Allergy and Applied Immunology
Volume46
Issue number4
StatePublished - Dec 1 1974

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