Simple methods for the titration of rabbit C1 and C5-9 have been developed which do not require purified complement components. The stable cellular intermediate, sheep erythrocyte - rabbit antibody - bovine complement C4 and C2 (SHEACBo42) is used for these assay methods with kinetic studies on the interaction between rabbit C1 and C5-9 with SHEACBo42 forming the basis for the methods. Furthermore, these assay methods have many applications for the evaluation of in vivo complement activation of both the classical and alternate pathways.
|Original language||English (US)|
|Number of pages||13|
|Journal||International Archives of Allergy and Applied Immunology|
|State||Published - Dec 1 1974|