TY - JOUR
T1 - Simple, efficient and flexible method to create biocompatible surfaces
AU - Alcantar, N. A.
AU - Aydil, E. S.
AU - Israelachvili, J. N.
N1 - Copyright:
Copyright 2004 Elsevier Science B.V., Amsterdam. All rights reserved.
PY - 1997
Y1 - 1997
N2 - A monolayer of polyethylene glycol (PEG) attached to a surface can resist protein adhesion and biological attack, making such a surface biocompatible. We describe a method for grating short-chain PEG molecules onto amorphous silica surfaces. Amorphous silicon dioxide films are deposited by plasma enhanced chemical vapor deposition (PECVD), and activated by exposing the surface to water plasma. Then, a monolayer of thin PEG film is produced by reacting PEG with silanol (SiOH) groups on the activated silica to form a Si-O-C ester linkage. This method is flexible because silica can be easily deposited on various materials including metals and plastics by PECVD, and it is efficient because it involves a direct reaction between the PEG molecule and the amorphous silica film. We discuss the synthesis and characterization of silica and PEG films by attenuated total reflection spectroscopy, ellipsometry and atomic force microscopy.
AB - A monolayer of polyethylene glycol (PEG) attached to a surface can resist protein adhesion and biological attack, making such a surface biocompatible. We describe a method for grating short-chain PEG molecules onto amorphous silica surfaces. Amorphous silicon dioxide films are deposited by plasma enhanced chemical vapor deposition (PECVD), and activated by exposing the surface to water plasma. Then, a monolayer of thin PEG film is produced by reacting PEG with silanol (SiOH) groups on the activated silica to form a Si-O-C ester linkage. This method is flexible because silica can be easily deposited on various materials including metals and plastics by PECVD, and it is efficient because it involves a direct reaction between the PEG molecule and the amorphous silica film. We discuss the synthesis and characterization of silica and PEG films by attenuated total reflection spectroscopy, ellipsometry and atomic force microscopy.
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M3 - Conference article
AN - SCOPUS:0030646228
SN - 0743-0515
VL - 76
SP - 619
JO - Polymeric Materials Science and Engineering, Proceedings of the ACS Division of Polymeric Materials Science and Engineering
JF - Polymeric Materials Science and Engineering, Proceedings of the ACS Division of Polymeric Materials Science and Engineering
T2 - Proceedings of the 1997 Spring ACS Meeting
Y2 - 13 April 1997 through 17 April 1997
ER -