Similarity study of proteomic maps

Marjan Vracko, Subhash C. Basak

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

In the presented work, we propose two approaches to study the similarity between proteomic maps. First, we introduced similarity index as a robust parameter to express the degree of similarity among proteomic maps. Second, we treated the proteomic maps with self-organizing map (SOM) technique taking the abundances of spots as input variables. The study was performed on a set of reported proteomic maps, which were experimentally derived from mouse liver after the animals were treated with peroxisome proliferators. (Entire study included five peroxisome proliferators, control, and a non-peroxisome proliferating compound.) In original paper, the authors analyzed the data with the principal component method. Later other authors reported the study on the same data set using different numerical representations of proteomic maps. The presented results are in agreement with reported conclusions.

Original languageEnglish (US)
Pages (from-to)33-38
Number of pages6
JournalChemometrics and Intelligent Laboratory Systems
Volume70
Issue number1
DOIs
StatePublished - Jan 28 2004

Keywords

  • Peroxisome proliferators
  • Proteomic maps
  • Self-organizing map
  • Similarity index

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