Similarity of the C. elegans developmental timing protein LIN-42 to circadian rhythm proteins

Mili Jeon, Heather F. Gardner, Eric A. Miller, Jodie Deshler, Ann E. Rougvie

Research output: Contribution to journalArticlepeer-review

145 Scopus citations

Abstract

The Caenorhabditis elegans heterochronic genes control the relative timing and sequence of many events during postembryonic development, including the terminal differentiation of the lateral hypodermis, which occurs during the final (fourth) molt. Inactivation of the heterochronic gene lin-42 causes hypodermal terminal differentiation to occur precociously, during the third molt. LIN-42 most closely resembles the Period family of proteins from Drosophila and other organisms, proteins that function in another type of biological timing mechanism: the timing of circadian rhythms. Per mRNA levels oscillate with an approximately 24-hour periodicity, lin-42 mRNA levels also oscillate, but with a faster rhythm; the oscillation occurs relative to the approximately 6-hour molting cycles of postembryonic development.

Original languageEnglish (US)
Pages (from-to)1141-1146
Number of pages6
JournalScience
Volume286
Issue number5442
DOIs
StatePublished - Nov 5 1999

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