Simian virus 40 T antigen can regulate p53-mediated transcription independent of binding p53

J. J. Rushton; D. Jiang; A. Srinivasan; J. M. Pipas; P. D. Robbins

doi:10.1128/jvi.71.7.5620-5623.1997

Simian virus 40 T antigen can regulate p53-mediated transcription independent of binding p53

J. J. Rushton, D. Jiang, A. Srinivasan, J. M. Pipas, P. D. Robbins

Research output: Contribution to journal › Article › peer-review

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Abstract

A simian virus 40 (SV40) T-antigen mutant containing only the N-terminal 136 amino acids, able to bind to Rb and p300 but not p53, partially inhibited p53-mediated transcription without affecting the ability of p53 to bind DNA. These results suggest that SV40 T antigen can regulate p53-mediated transcription either directly through protein-protein association or indirectly through interaction with factors which may function to confer p53- mediated transcription.

Original language	English (US)
Pages (from-to)	5620-5623
Number of pages	4
Journal	Journal of virology
Volume	71
Issue number	7
DOIs	https://doi.org/10.1128/jvi.71.7.5620-5623.1997
State	Published - 1997
Externally published	Yes

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abstract = "A simian virus 40 (SV40) T-antigen mutant containing only the N-terminal 136 amino acids, able to bind to Rb and p300 but not p53, partially inhibited p53-mediated transcription without affecting the ability of p53 to bind DNA. These results suggest that SV40 T antigen can regulate p53-mediated transcription either directly through protein-protein association or indirectly through interaction with factors which may function to confer p53- mediated transcription.",

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AU - Rushton, J. J.

AU - Jiang, D.

AU - Srinivasan, A.

AU - Pipas, J. M.

AU - Robbins, P. D.

PY - 1997

Y1 - 1997

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AB - A simian virus 40 (SV40) T-antigen mutant containing only the N-terminal 136 amino acids, able to bind to Rb and p300 but not p53, partially inhibited p53-mediated transcription without affecting the ability of p53 to bind DNA. These results suggest that SV40 T antigen can regulate p53-mediated transcription either directly through protein-protein association or indirectly through interaction with factors which may function to confer p53- mediated transcription.

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Simian virus 40 T antigen can regulate p53-mediated transcription independent of binding p53

Abstract

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