Simian virus 40 T antigen can regulate p53-mediated transcription independent of binding p53

J. J. Rushton, D. Jiang, A. Srinivasan, J. M. Pipas, P. D. Robbins

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

A simian virus 40 (SV40) T-antigen mutant containing only the N-terminal 136 amino acids, able to bind to Rb and p300 but not p53, partially inhibited p53-mediated transcription without affecting the ability of p53 to bind DNA. These results suggest that SV40 T antigen can regulate p53-mediated transcription either directly through protein-protein association or indirectly through interaction with factors which may function to confer p53- mediated transcription.

Original languageEnglish (US)
Pages (from-to)5620-5623
Number of pages4
JournalJournal of virology
Volume71
Issue number7
DOIs
StatePublished - 1997
Externally publishedYes

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