Sildenafil increases uterine blood flow in nonpregnant nulliparous women

Sarah A. Hale, Cresta W. Jones, George Osol, Adrienne Schonberg, Gary J. Badger, Ira M. Bernstein

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


This study investigated the effect of sildenafil on uterine volumetric blood flow (UVF) and vascular impedance in nonpregnant, nulliparous women. Fifteen women were randomized in a double-blind fashion to receive either placebo or sildenafil (25 or 100 mg) during the luteal phase of the menstrual cycle. Color Doppler ultrasound of both uterine arteries was performed at baseline and at 1 and 3 hours postdosing to calculate resistance index (RI) and UVF. Those who received sildenafil significantly increased UVF and decreased RI over the 3-hour monitoring period. When UVF responses to sildenafil were examined as a function of baseline UVF, a significant increase in UVF was observed in only those participants with higher baseline UVF. Overall, women in the luteal phase demonstrated a significant increase in UVF in response to sildenafil. However, this increase appears to be directly associated with basal UVF.

Original languageEnglish (US)
Pages (from-to)358-365
Number of pages8
JournalReproductive Sciences
Issue number4
StatePublished - Apr 2010
Externally publishedYes


  • Flow-mediated vasodilation
  • Sildenafil
  • Uterine volumetric blood flow


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