Significantly improved analytical sensitivity of lateral flow immunoassays by using thermal contrast

Zhenpeng Qin, Warren C.W. Chan, David R Boulware, Taner Akkin, Elissa K. Butler, John C Bischof

Research output: Contribution to journalArticlepeer-review

92 Scopus citations

Abstract

Heat beyond visual: The thermal contrast from the heating of gold nanoparticles upon laser stimulation can improve the analytical sensitivity of lateral flow assays (LFAs; see picture). A 32-fold improvement in sensitivity of an approved LFA for cryptococcal antigen (purple diamond) was shown, with the potential for further improvement by optimizing the backing material and the properties of the antibody-coated nanoparticles (red circle with blue Y).

Original languageEnglish (US)
Pages (from-to)4358-4361
Number of pages4
JournalAngewandte Chemie - International Edition
Volume51
Issue number18
DOIs
StatePublished - Apr 27 2012

Keywords

  • biosensors
  • diagnostics
  • immunoassays
  • nanoparticles
  • thermal contrast

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