Parkinson disease (PD) is the second most common neurodegenerative disorder, surpassed in frequency only by Alzheimer disease. Elsewhere we have reported linkage to chromosome 2q in a sample of sibling pairs with PD. We have now expanded our sample to include 150 families meeting our strictest diagnostic definition of verified PD. To further delineate the chromosome 2q linkage, we have performed analyses using only those pedigrees with the strongest family history of PD. Linkage analyses in this subset of 65 pedigrees generated a LOD score of 5.1, which was obtained using an autosomal dominant model of disease transmission. This result strongly suggests that variation in a gene on chromosome 2q36-37 contributes to PD susceptibility.
Bibliographical noteFunding Information:
This project was supported by National Institutes of Health grant R01 NS37167. We thank the subjects for their participation in this research study. Parkinson Study Group Investigators are as follows: Steering Committee—Lawrence Golbe, M.D., UMDNJ Robert Wood Johnson Medical Center, New Brunswick, NJ; William Koller, M.D., Mt. Sinai Medical Center, New York; Kelly Lyons, Ph.D., University of Miami, Miami; Karen Marder, M.D., Columbia-Presbyterian Medical Center, New York; Frederick Marshall, M.D., David Oakes, Ph.D., and Alice Rudolph, Ph.D., University of Rochester, Rochester, NY; Cliff Shults, M.D., University of California San Diego, San Diego; Aileen Shinaman, J.D., University of Rochester, Rochester, NY; and Eric Siemers, Eli Lilly & Company, Indianapolis. Participating Investigators and Coordinators—Joanne Wojcieszek, M.D., and Joann Belden, R.N., Indiana University School of Medicine, Indianapolis; Julie Carter, R.N., M.N., A.N.P., Richard Camicioli, M.D., and Pamela Andrews, R.N., Oregon Health Sciences University, Portland, OR; Magali Fernandez, M.D., Jean Hubble, M.D., and Carson Reider, Ph.D., Ohio State University, Columbus, OH; Ali Rajput, M.D., Alex Rajput, M.D., and Theresa Shirley, R.N., Saskatoon Health District Board, Saskatoon, Saskatchewan, Canada; Michel Panisset, M.D., and Jean Hall, R.N., McGill Centre for Studies in Aging, Verdun, Quebec, Canada; Tilak Mendis, M.D., David A. Grimes, M.D., and Peggy Gray, R.N., B.S.C.N., Ottawa Civic Hospital, Ottawa, Ontario, Canada; Carmen Serrano Ramos, M.D., Sandra Roque, R.N., University of Puerto Rico School of Medicine, San Juan, Puerto Rico; Stephen Reich, M.D., and Becky Dunlop, R.N., Johns Hopkins University, Baltimore; Robert Hauser, M.D., Juan Sanchez-Ramos, M.D., Theresa Zesiewicz, M.D., and Holly Delgado, R.N., University of South Florida, Tampa, FL; Joseph Friedman, M.D., Hubert Fernandez, M.D., and Margaret Lannon, R.N., M.S., Brown University, Pawtucket, RI; Lauren Seeberger, M.D., Christopher O’Brien, M.D., and Deborah Judd, R.N., Colorado Neurological Institute, Englewood, CO; Lawrence Elmer, M.D., Ph.D., Kathy Davis, R.N., M.S.N., Medical College of Ohio, Toledo, OH; Cliff Shults, M.D., and Deborah Fontaine, R.N.C., G.N.P., University of California San Diego, San Diego; Ronald Pfeiffer, M.D., and Brenda Pfeiffer, R.N., B.S.N., University of Tennessee-Memphis, Memphis, TN; Michael Aminoff, M.D., F.R.C.P., and Mariann DiMinno, University of California San Francisco, San Francisco; Daniel Truong, M.D., Mayank Pathak, M.D., and Anhoa Tran, R.N., Parkinson’s and Movement Disorder Institute, Fountain Valley, CA; Robert Rodnitzky, M.D., and Judith Dobson, R.N., University of Iowa, Iowa City, IA; Rajesh Pahwa, M.D., and Stephanie Thomas, L.P.N., Kansas University Medical Center, Kansas City, KS; Danna Jennings, M.D., Kenneth Marek, M.D., and Susan Mendick, M.P.H., Institute for Neurodegenerative Disorders, New Haven, CT; Karen Marder, M.D., and Juliette Harris, M.S., Ph.D., Columbia-Presbyterian Medical Center, New York; William Koller, M.D., William Weiner, M.D., and Kelly Lyons, Ph.D., University of Miami, Miami; Roger Kurlan, M.D., and Debra Berry, M.S.N., N.P., University of Rochester Medical Center, Rochester, NY; Peter Lewitt, M.D., and Maryan DeAngelis, R.N., Clinical Neuroscience Center, West Bloomfield, MI; Paul Tuite, M.D., and Robyn Schacherer, R.N., University of Minnesota, Minneapolis; Wayne Martin, M.D., and Marguerite Wieler, B.S.C., P.T., University of Alberta, Edmonton, Alberta, Canada; Bala Manyam, M.D., and Patricia Simpson, R.N., B.S.N, Scott & White Hospital/Texas A&M University, Temple, TX; John Bertoni, M.D., Ph.D., and Carolyn Peterson, R.N., Creighton University, Omaha; Mark F. Gordon, M.D., and Joanna Hamann, Long Island Jewish Medical Center, New Hyde Park, NY; Joseph Jankovic, M.D., and Christine Hunter, R.N., Baylor College of Medicine, Houston; Stewart Factor, D.O., and Sharon Evans, L.P.N., Albany Medical College, Albany, NY; Anette Nieves, M.D., and Julie So, R.N., Toronto Western Hospital, Toronto; Mark Stacy, M.D., and Kelli Williamson, R.N., Barrow Neurological Institute, Phoenix; Francis Walker, M.D., and Victoria Hunt, R.N., Wake Forest University School of Medicine, Winston-Salem, NC; Un Jung Kang, M.D., and Shirley Uy, University of Chicago, Chicago; Karen Blindauer, M.D., and Jeannine Petit, C.N.R.N., G.N.P.C., Medical College of Wisconsin, Milwaukee; David Simon, M.D., and Lisa Scollins, R.N., Beth Israel Deaconess Medical Center, Boston; Rachel Saunders Pullman, M.D., and Karyn Boyar R.N.C, M.S., F.N.P., Beth Israel Medical Center, New York; Paul Gordon, M.D., and Joan Werner, University of New Mexico, Albuquerque; Brad Racette, M.D., and Laura Good, R.N., Washington University, St. Louis; Miodrag Velickovic, M.D., and Sabrina Phipps, Mount Sinai Medical Center, New York; Arif Dalvi, M.D., and Donna Schweiterman M.A., C.C.R.C., University of Cincinnati Medical Center, Cincinnati; Maureen Leehey, M.D., and Sharon Culver, A.N.P., University of Colorado Health Sciences Center, Denver; Mandar Jog, M.D., Ph.D., and Cheryl Horn, R.N., London Health Sciences Center, London, Ontario, Canada; Jayaraman Rao, M.D., Maureen Cook, R.N., B.S.N., Louisiana State University Medical Center, New Orleans; Kapil Sethi, M.D., and Joan Carpenter, R.N., Medical College of Georgia, Augusta, GA; Paul Atchison, M.D., and Cathy Allen, R.N., B.S.N., University of Alabama-Birmingham, Birmingham; Lewis Sudarsky, M.D., Claire Corwin, P.A.C., B.S., Brigham & Women’s Hospital, Boston; Tanya Simuni, M.D., and Michele Wolff B.A., Northwestern University Medical School, Chicago; Richard Dewey, M.D., and Melinda Jones, R.N., B.S.N., University of Texas Southwestern Medical Center, Dallas; Neal Hermanowicz, M.D., and Cheryl Dutton, R.N., M.S., University of California, Irvine, Irvine, CA; G. David Podskalny, M.D., and Lisa Giffin, L.P.N., University of Medicine and Dentistry of New Jersey, Stratford, NJ; Andrew Feigin, M.D., and Barbara Shannon, R.N., North Shore University Hospital, Manhasset, NY; Vincent Calabrese, M.D., and Peggy Roberge, R.N., Hunter Homes McGuire Veterans Medical Center, Richmond, VA; James Sutton, M.D., and Brad Hutchinson, C.C.R.C., California Medical Clinic for Movement Disorders, Oxnard, CA; Lisa Shulman, M.D., and Kelly Dustin, R.N., University of Maryland School of Medicine, Baltimore; Todd Ajax, M.D., and Janet Mannetter, R.N., McFarland Clinic, Mary Greely Hospital, Ames, IA; Oksana Suchowersky, M.D., and Mary Lou Klimek, R.N., B.N., M.A., University of Calgary, Calgary, Alberta, Canada; and Ryan Uitti, M.D., and Margaret Foster Turk, R.N., Mayo Clinic Jacksonville, Jacksonville, FL. Biostatistics and Clinical Trials Coordination Center’s Staff—David Oakes, Ph.D., Arthur Watts, B.S., Antai Wang, M.A., Tori Ross, M.A., Susan Bennett, A.A.S., Elaine Julian-Baros, and Susan Daigneault, University of Rochester, Rochester, NY.