Significant expansion of the solid state landscape of salicylic acid based on charge-assisted hydrogen bonding interactions

Benyong Lou; Sathyanarayana R. Perumalla; Changquan Calvin Sun

doi:10.1021/cg501496a

Significant expansion of the solid state landscape of salicylic acid based on charge-assisted hydrogen bonding interactions

Benyong Lou, Sathyanarayana R. Perumalla, Changquan Calvin Sun

Pharmaceutics

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Successful cocrystallization between a salicylate salt with salicylic acid and chemically distinct carboxylic acids suggests the robustness of the carboxylic acid-carboxylate supramolecular synthon. This type of robust synthon involving charge-assisted hydrogen bonding interactions has the potential to significantly expand the solid-state landscape of ionizable molecules.

Original language	English (US)
Pages (from-to)	24-28
Number of pages	5
Journal	Crystal Growth and Design
Volume	15
Issue number	1
DOIs	https://doi.org/10.1021/cg501496a
State	Published - Jan 7 2015

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© 2014 American Chemical Society.

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title = "Significant expansion of the solid state landscape of salicylic acid based on charge-assisted hydrogen bonding interactions",

abstract = "Successful cocrystallization between a salicylate salt with salicylic acid and chemically distinct carboxylic acids suggests the robustness of the carboxylic acid-carboxylate supramolecular synthon. This type of robust synthon involving charge-assisted hydrogen bonding interactions has the potential to significantly expand the solid-state landscape of ionizable molecules.",

author = "Benyong Lou and Perumalla, \{Sathyanarayana R.\} and Sun, \{Changquan Calvin\}",

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AU - Sun, Changquan Calvin

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Y1 - 2015/1/7

N2 - Successful cocrystallization between a salicylate salt with salicylic acid and chemically distinct carboxylic acids suggests the robustness of the carboxylic acid-carboxylate supramolecular synthon. This type of robust synthon involving charge-assisted hydrogen bonding interactions has the potential to significantly expand the solid-state landscape of ionizable molecules.

AB - Successful cocrystallization between a salicylate salt with salicylic acid and chemically distinct carboxylic acids suggests the robustness of the carboxylic acid-carboxylate supramolecular synthon. This type of robust synthon involving charge-assisted hydrogen bonding interactions has the potential to significantly expand the solid-state landscape of ionizable molecules.

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Significant expansion of the solid state landscape of salicylic acid based on charge-assisted hydrogen bonding interactions

Abstract

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