Significant differences in coeliac immunotoxicity of barley varieties

Isabel Comino, Ana Real, Javier Gil-Humanes, Fernando Pistón, Laura de Lorenzo, Ma de Lourdes Moreno, Miguel Ángel López-Casado, Pedro Lorite, Ángel Cebolla, Ma Isabel Torres, Francisco Barro, Carolina Sousa

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


Scope: The only treatment available for coeliac disease (CD) is a strict diet in which the intake of wheat, barley, rye, or oats is avoided. Barley is a major cereal crop, grown mainly for its use in brewing, and it has high nutritional value. The identification of varieties with a reduced toxicity profile may contribute to improve the diet, the quality of life and health of CD patients. Methods and results: Searching for harmless barleys, we investigated accessions of malting and wild barley, used for developing new cultivated cereals. The CD toxicity profile of barleys was screened using G12 antibody and cell proliferation and IFN-γ release from peripheral blood mononuclear cells and intestinal biopsies from CD patients. We found a direct correlation between the reactivity with G12 and the immunogenicity of the different barleys. Conclusion: The malting barleys were less immunogenic, with reduced levels of toxic gluten, and were possibly less harmful to CD patients. Our findings could raise the prospect of breeding barley species with low levels of harmful gluten, and the attractive goal of developing nontoxic barley cultivars, always taking into account the Codex standard for foods for special dietary use for persons intolerant to gluten.

Original languageEnglish (US)
Pages (from-to)1697-1707
Number of pages11
JournalMolecular Nutrition and Food Research
Issue number11
StatePublished - Nov 2012
Externally publishedYes


  • 33-mer
  • Barley
  • Coeliac disease
  • Interferon-gamma
  • Monoclonal antibody


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