Significance of granulomatous inflammation in usual interstitial pneumonia

Research output: Contribution to journalArticle

Abstract

Sarcoidosis is a systemic granulomatous disease of unclear etiology with characteristic pulmonary lesions. We describe 2 unique cases of sarcoidosis where after approximately 20 years of clinical quiescence, patients developed interstitial opacities on chest CT scan and an increase in shortness of breath. With lack of therapeutic response to a course of prednisone, both patients underwent a surgical lung biopsy that revealed a pattern consistent with Usual Interstitial Pneumonia (UIP) with honeycombing and fibroblastic foci. Postoperatively, the course of the disease was consistent with what would be expected in Idiopathic Pulmonary Fibrosis. Ultimately the disease progressed with one patient needed lung transplantation and the other requiring highflow oxygen supplementation. In conclusion, we present two patients in whom a diagnosis of sarcoidosis preceded the diagnosis of UIP by 20 years or more.

Original languageEnglish (US)
Pages (from-to)160-166
Number of pages7
JournalSarcoidosis Vasculitis and Diffuse Lung Diseases
Volume32
Issue number2
StatePublished - Jan 1 2015

Keywords

  • Granulomas
  • IPF
  • Sarcoidosis
  • UIP

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