Signaling through Free Fatty Acid Receptor 4 Attenuates Cardiometabolic Disease

Timothy D. O’connell; Katie Murphy; Naixin Zhang; Sara J. Puccini; Chastity L Healy; Brian A. Harsch; Michael J. Zhang; Gregory C. Shearer

doi:10.1152/physiol.00007.2022

Signaling through Free Fatty Acid Receptor 4 Attenuates Cardiometabolic Disease

Timothy D. O’connell, Katie Murphy, Naixin Zhang, Sara J. Puccini, Chastity L Healy, Brian A. Harsch, Michael J. Zhang, Gregory C. Shearer

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

A surge in the prevalence of obesity and metabolic syndrome, which promote systemic inflammation, underlies an increase in cardiometabolic disease. Free fatty acid receptor 4 is a nutrient sensor for long-chain fatty acids, like ω3-poly-unsaturated fatty acids (ω3-PUFAs), that attenuates metabolic disease and resolves inflammation. Clinical trials indicate ω3-PUFAs are cardioprotective, and this review discusses the mechanistic links between ω3-PUFAs, free fatty acid receptor 4, and attenuation of cardiometabolic disease.

Original language	English (US)
Pages (from-to)	311-322
Number of pages	12
Journal	Physiology
Volume	37
Issue number	6
DOIs	https://doi.org/10.1152/physiol.00007.2022
State	Published - Nov 2022

Bibliographical note

Funding Information:
This work was supported by National Institutes of Health (NIH) Grants 1R01HL130099 (to T.D.O. and G.C.S.) and 1R01HL152215 (to T.D.O. and G.C.S.), Minnesota Obesity Prevention Training Program T32 NIH Grant 1T32DK083250-01A1 (to K.A.M.), and NIH Post-doctoral Fellowship F32HL152523 (to M.Z.).

Publisher Copyright:
© 2022 Int. Union Physiol. Sci./Am. Physiol. Soc.

Keywords

18-hydroxyeico-sapentaenoic acid (18-HEPE)
cardiometabolic disease
free fatty acid receptor 4 (Ffar4)
heart
speci-alized proresolving mediators (SPM)
ω3-polyunsaturated fatty acids (ω3-PUFAs)

PubMed: MeSH publication types

Journal Article
Review
Research Support, N.I.H., Extramural

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1152/physiol.00007.2022

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abstract = "A surge in the prevalence of obesity and metabolic syndrome, which promote systemic inflammation, underlies an increase in cardiometabolic disease. Free fatty acid receptor 4 is a nutrient sensor for long-chain fatty acids, like ω3-poly-unsaturated fatty acids (ω3-PUFAs), that attenuates metabolic disease and resolves inflammation. Clinical trials indicate ω3-PUFAs are cardioprotective, and this review discusses the mechanistic links between ω3-PUFAs, free fatty acid receptor 4, and attenuation of cardiometabolic disease.",

keywords = "18-hydroxyeico-sapentaenoic acid (18-HEPE), cardiometabolic disease, free fatty acid receptor 4 (Ffar4), heart, speci-alized proresolving mediators (SPM), ω3-polyunsaturated fatty acids (ω3-PUFAs)",

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note = "Funding Information: This work was supported by National Institutes of Health (NIH) Grants 1R01HL130099 (to T.D.O. and G.C.S.) and 1R01HL152215 (to T.D.O. and G.C.S.), Minnesota Obesity Prevention Training Program T32 NIH Grant 1T32DK083250-01A1 (to K.A.M.), and NIH Post-doctoral Fellowship F32HL152523 (to M.Z.). Publisher Copyright: {\textcopyright} 2022 Int. Union Physiol. Sci./Am. Physiol. Soc.",

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doi = "10.1152/physiol.00007.2022",

language = "English (US)",

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AU - Harsch, Brian A.

AU - Zhang, Michael J.

AU - Shearer, Gregory C.

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AB - A surge in the prevalence of obesity and metabolic syndrome, which promote systemic inflammation, underlies an increase in cardiometabolic disease. Free fatty acid receptor 4 is a nutrient sensor for long-chain fatty acids, like ω3-poly-unsaturated fatty acids (ω3-PUFAs), that attenuates metabolic disease and resolves inflammation. Clinical trials indicate ω3-PUFAs are cardioprotective, and this review discusses the mechanistic links between ω3-PUFAs, free fatty acid receptor 4, and attenuation of cardiometabolic disease.

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KW - free fatty acid receptor 4 (Ffar4)

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Signaling through Free Fatty Acid Receptor 4 Attenuates Cardiometabolic Disease

Abstract

Bibliographical note

Keywords

PubMed: MeSH publication types

UN SDGs

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