Signal transduction pathways: Targets for green and black tea polyphenols

Ann M. Bode, Zigang Dong

Research output: Contribution to journalReview articlepeer-review

98 Scopus citations

Abstract

Tea is one of the most popular beverages consumed in the world and has been demonstrated to have anti-cancer activity in animal models. Research findings suggest that the polyphenolic compounds, (-)-epigallocatechin-3-gallate found primarily in green tea, and theaflavin-3,3′-digallate, a major component of black tea, are the two most effective anti-cancer factors found in tea. Several mechanisms to explain the chemopreventive effects of tea have been presented but others and we suggest that tea components target specific cell-signaling pathways responsible for regulating cellular proliferation or apoptosis. These pathways include signal transduction pathways leading to activator protein-1 (AP-1) and/or nuclear factor kappa B (NF-κB). AP-1 and NF-κB are transcription factors that are known to he extremely important in tumor promoter-induced cell transformation and tumor promotion, and both are influenced differentially by the MAP kinase pathways. The purpose of this brief review is to present recent research data from other and our laboratory focusing on the tea-induced cellular signal transduction events associated with the MAP kinase, AP-1, and NF-κB pathways.

Original languageEnglish (US)
Pages (from-to)66-77
Number of pages12
JournalJournal of Biochemistry and Molecular Biology
Volume36
Issue number1
DOIs
StatePublished - Jan 31 2003

Keywords

  • Activator protein-1
  • Apoptosis
  • EGCG
  • Nuclear factor kappa B
  • Theaflavins
  • Tumor promotion

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