Abstract
Environmental and life-style aspects are major contributors to human carcinogenesis and, therefore, many human cancers may be preventable. Cancer is the end result of defects in cellular signaling processes that play a key role in the control of cell growth, survival, division, and differentiation. Therefore, identifying molecular and cellular targets critical in cancer development and prevention is an area of intensive research, driving the development of highly specific small-molecule inhibitors. A major idea today is that cancer may be prevented or treated by targeting the products of specific cancer-related genes, frequently encoding signaling proteins or transcription factors. Participants in these joint conferences discussed their latest findings in the identification of promising molecular targets and the development of agents directed against these targets with the goal of effectively transitioning these into the clinical setting.
| Original language | English (US) |
|---|---|
| Journal | Science Signaling |
| Volume | 2 |
| Issue number | 59 |
| DOIs | |
| State | Published - Feb 24 2009 |
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Signal transduction molecules as targets for cancer prevention. / Bode, Ann M.; Dong, Zigang.
In: Science Signaling, Vol. 2, No. 59, 24.02.2009.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Signal transduction molecules as targets for cancer prevention
AU - Bode, Ann M.
AU - Dong, Zigang
PY - 2009/2/24
Y1 - 2009/2/24
N2 - Environmental and life-style aspects are major contributors to human carcinogenesis and, therefore, many human cancers may be preventable. Cancer is the end result of defects in cellular signaling processes that play a key role in the control of cell growth, survival, division, and differentiation. Therefore, identifying molecular and cellular targets critical in cancer development and prevention is an area of intensive research, driving the development of highly specific small-molecule inhibitors. A major idea today is that cancer may be prevented or treated by targeting the products of specific cancer-related genes, frequently encoding signaling proteins or transcription factors. Participants in these joint conferences discussed their latest findings in the identification of promising molecular targets and the development of agents directed against these targets with the goal of effectively transitioning these into the clinical setting.
AB - Environmental and life-style aspects are major contributors to human carcinogenesis and, therefore, many human cancers may be preventable. Cancer is the end result of defects in cellular signaling processes that play a key role in the control of cell growth, survival, division, and differentiation. Therefore, identifying molecular and cellular targets critical in cancer development and prevention is an area of intensive research, driving the development of highly specific small-molecule inhibitors. A major idea today is that cancer may be prevented or treated by targeting the products of specific cancer-related genes, frequently encoding signaling proteins or transcription factors. Participants in these joint conferences discussed their latest findings in the identification of promising molecular targets and the development of agents directed against these targets with the goal of effectively transitioning these into the clinical setting.
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UR - http://www.scopus.com/inward/citedby.url?scp=66149113319&partnerID=8YFLogxK
U2 - 10.1126/scisignal.259mr2
DO - 10.1126/scisignal.259mr2
M3 - Article
VL - 2
JO - Science Signaling
JF - Science Signaling
SN - 1937-9145
IS - 59
ER -