Signal transduction molecules as targets for cancer prevention

Ann M. Bode, Zigang Dong

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Environmental and life-style aspects are major contributors to human carcinogenesis and, therefore, many human cancers may be preventable. Cancer is the end result of defects in cellular signaling processes that play a key role in the control of cell growth, survival, division, and differentiation. Therefore, identifying molecular and cellular targets critical in cancer development and prevention is an area of intensive research, driving the development of highly specific small-molecule inhibitors. A major idea today is that cancer may be prevented or treated by targeting the products of specific cancer-related genes, frequently encoding signaling proteins or transcription factors. Participants in these joint conferences discussed their latest findings in the identification of promising molecular targets and the development of agents directed against these targets with the goal of effectively transitioning these into the clinical setting.

Original languageEnglish (US)
JournalScience Signaling
Volume2
Issue number59
DOIs
StatePublished - Feb 24 2009

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Cell signaling
Signal transduction
Gene encoding
Cell growth
Signal Transduction
Transcription Factors
Defects
Molecules
Neoplasms
Proteins
Neoplasm Genes
Life Style
Cell Survival
Carcinogenesis
Joints
Growth
Research

Cite this

Signal transduction molecules as targets for cancer prevention. / Bode, Ann M.; Dong, Zigang.

In: Science Signaling, Vol. 2, No. 59, 24.02.2009.

Research output: Contribution to journalArticle

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