Signal transduction in T lymphocytes

Erik J. Peterson, G. A. Koretzky

Research output: Contribution to journalReview articlepeer-review

22 Scopus citations


T lymphocytes utilize a variety of surface receptors to transmit environmental signals across the plasma membrane and initiate biochemical events leading to responses such as proliferation, anergy, cytokine secretion, and death. The T cell receptor complex, CD28, IL-2 receptor, and CD95 each couple to distinct sets of cytoplasmic signaling events to modulate the biological responses of T cells. Deficiency or defective function of proteins involved in signaling through these receptors are associated with murine and human disease.

Original languageEnglish (US)
Pages (from-to)107-114
Number of pages8
JournalClinical and Experimental Rheumatology
Issue number1
StatePublished - Mar 5 1999


  • CD28
  • CD95
  • IL-2 receptor
  • Signal transduction
  • T cell receptor (TCR)


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