Abstract
T lymphocytes utilize a variety of surface receptors to transmit environmental signals across the plasma membrane and initiate biochemical events leading to responses such as proliferation, anergy, cytokine secretion, and death. The T cell receptor complex, CD28, IL-2 receptor, and CD95 each couple to distinct sets of cytoplasmic signaling events to modulate the biological responses of T cells. Deficiency or defective function of proteins involved in signaling through these receptors are associated with murine and human disease.
Original language | English (US) |
---|---|
Pages (from-to) | 107-114 |
Number of pages | 8 |
Journal | Clinical and Experimental Rheumatology |
Volume | 17 |
Issue number | 1 |
State | Published - Mar 5 1999 |
Keywords
- CD28
- CD95
- IL-2 receptor
- Signal transduction
- T cell receptor (TCR)