Signal transduction events regulating integrin function and T cell migration new functions and complexity

Jonathan T. Pribila, Yoji Shimizu

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations

Abstract

Integrin receptors facilitate T cell function by mediating adhesive events critical for T cell trafficking and recognition of foreign antigen, including interactions with vascular endothelium, extracellular matrix components, and antigen-presenting cells. Consequently, the functional activity of integrin receptors is acutely regulated by various intracellular signals delivered by other cell surface receptors, resulting in rapid changes in T cell adhesion and migration. This review highlights recent insights into our understanding of the signaling events by which the CD3/T cell receptor complex and chemokine receptors regulate integrin function and T cell migration. These studies highlight novel functions for several signaling molecules, including the tyrosine kinases Itk and ZAP-70, and the adapter protein SLAP-130/Fyb. In addition, analysis of the regulation of integrin function and chemokine-mediated migration has highlighted the critical role that spatial localization of signaling molecules plays in signal transduction, and the importance of the actin cytoskeleton in T cell function.

Original languageEnglish (US)
Pages (from-to)107-128
Number of pages22
JournalImmunologic Research
Volume27
Issue number1
DOIs
StatePublished - Apr 1 2003

Keywords

  • Adhesion
  • Chemokine
  • Integrin
  • Migration
  • Signal transduction
  • T lymphocyte

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