Abstract
Integrin receptors facilitate T cell function by mediating adhesive events critical for T cell trafficking and recognition of foreign antigen, including interactions with vascular endothelium, extracellular matrix components, and antigen-presenting cells. Consequently, the functional activity of integrin receptors is acutely regulated by various intracellular signals delivered by other cell surface receptors, resulting in rapid changes in T cell adhesion and migration. This review highlights recent insights into our understanding of the signaling events by which the CD3/T cell receptor complex and chemokine receptors regulate integrin function and T cell migration. These studies highlight novel functions for several signaling molecules, including the tyrosine kinases Itk and ZAP-70, and the adapter protein SLAP-130/Fyb. In addition, analysis of the regulation of integrin function and chemokine-mediated migration has highlighted the critical role that spatial localization of signaling molecules plays in signal transduction, and the importance of the actin cytoskeleton in T cell function.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 107-128 |
| Number of pages | 22 |
| Journal | Immunologic Research |
| Volume | 27 |
| Issue number | 1 |
| DOIs | |
| State | Published - Apr 1 2003 |
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Keywords
- Adhesion
- Chemokine
- Integrin
- Migration
- Signal transduction
- T lymphocyte
Cite this
Signal transduction events regulating integrin function and T cell migration new functions and complexity. / Pribila, Jonathan T.; Shimizu, Yoji.
In: Immunologic Research, Vol. 27, No. 1, 01.04.2003, p. 107-128.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Signal transduction events regulating integrin function and T cell migration new functions and complexity
AU - Pribila, Jonathan T.
AU - Shimizu, Yoji
PY - 2003/4/1
Y1 - 2003/4/1
N2 - Integrin receptors facilitate T cell function by mediating adhesive events critical for T cell trafficking and recognition of foreign antigen, including interactions with vascular endothelium, extracellular matrix components, and antigen-presenting cells. Consequently, the functional activity of integrin receptors is acutely regulated by various intracellular signals delivered by other cell surface receptors, resulting in rapid changes in T cell adhesion and migration. This review highlights recent insights into our understanding of the signaling events by which the CD3/T cell receptor complex and chemokine receptors regulate integrin function and T cell migration. These studies highlight novel functions for several signaling molecules, including the tyrosine kinases Itk and ZAP-70, and the adapter protein SLAP-130/Fyb. In addition, analysis of the regulation of integrin function and chemokine-mediated migration has highlighted the critical role that spatial localization of signaling molecules plays in signal transduction, and the importance of the actin cytoskeleton in T cell function.
AB - Integrin receptors facilitate T cell function by mediating adhesive events critical for T cell trafficking and recognition of foreign antigen, including interactions with vascular endothelium, extracellular matrix components, and antigen-presenting cells. Consequently, the functional activity of integrin receptors is acutely regulated by various intracellular signals delivered by other cell surface receptors, resulting in rapid changes in T cell adhesion and migration. This review highlights recent insights into our understanding of the signaling events by which the CD3/T cell receptor complex and chemokine receptors regulate integrin function and T cell migration. These studies highlight novel functions for several signaling molecules, including the tyrosine kinases Itk and ZAP-70, and the adapter protein SLAP-130/Fyb. In addition, analysis of the regulation of integrin function and chemokine-mediated migration has highlighted the critical role that spatial localization of signaling molecules plays in signal transduction, and the importance of the actin cytoskeleton in T cell function.
KW - Adhesion
KW - Chemokine
KW - Integrin
KW - Migration
KW - Signal transduction
KW - T lymphocyte
UR - http://www.scopus.com/inward/record.url?scp=0037236082&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037236082&partnerID=8YFLogxK
U2 - 10.1385/IR:27:1:107
DO - 10.1385/IR:27:1:107
M3 - Review article
C2 - 12637771
AN - SCOPUS:0037236082
VL - 27
SP - 107
EP - 128
JO - Immunologic Research
JF - Immunologic Research
SN - 0257-277X
IS - 1
ER -