Ageing is defined by the loss of functional reserve over time, leading to a decreased tissue homeostasis and increased age-related pathology. The accumulation of damage including DNA damage contributes to driving cell signaling pathways that, in turn, can drive different cell fates, including senescence and apoptosis, as well as mitochondrial dysfunction and inflammation. In addition, the accumulation of cell autonomous damage with time also drives ageing through non-cell autonomous pathways by modulation of signaling pathways. Interestingly, genetic and pharmacologic analysis of factors able to modulate lifespan and healthspan in model organisms and even humans have identified several key signaling pathways including IGF-1, NF-κB, FOXO3, mTOR, Nrf-2 and sirtuins. This review will discuss the roles of several of these key signaling pathways, in particular NF-κB and Nrf2, in modulating ageing and age-related diseases.
|Original language||English (US)|
|Title of host publication||Subcellular Biochemistry|
|Publisher||Springer New York|
|Number of pages||21|
|State||Published - Mar 20 2019|
Bibliographical noteFunding Information:
Acknowledgements This work was supported by the NIH grants P01-AG043376 (PDR, LJN), U19-AG056278 (PDR, LJN, YS) and the Glenn/AFAR (LJN).
© 2019, Springer Nature Singapore Pte Ltd.
- Age-related disease
- NF-κB Nrf2
- Signaling pathways
- Signal Transduction/genetics
- Cellular Senescence
- NF-E2-Related Factor 2/metabolism
- NF-kappa B/metabolism
PubMed: MeSH publication types
- Journal Article