Signal transduction, ageing and disease

Lei Zhang; Matthew J. Yousefzadeh; Yousin Suh; Laura J. Niedernhofer; Paul D. Robbins

doi:10.1007/978-981-13-3681-2_9

Signal transduction, ageing and disease

Lei Zhang, Matthew J. Yousefzadeh, Yousin Suh, Laura J. Niedernhofer, Paul D. Robbins

Research output: Chapter in Book/Report/Conference proceeding › Chapter

33 Scopus citations

Abstract

Ageing is defined by the loss of functional reserve over time, leading to a decreased tissue homeostasis and increased age-related pathology. The accumulation of damage including DNA damage contributes to driving cell signaling pathways that, in turn, can drive different cell fates, including senescence and apoptosis, as well as mitochondrial dysfunction and inflammation. In addition, the accumulation of cell autonomous damage with time also drives ageing through non-cell autonomous pathways by modulation of signaling pathways. Interestingly, genetic and pharmacologic analysis of factors able to modulate lifespan and healthspan in model organisms and even humans have identified several key signaling pathways including IGF-1, NF-κB, FOXO3, mTOR, Nrf-2 and sirtuins. This review will discuss the roles of several of these key signaling pathways, in particular NF-κB and Nrf2, in modulating ageing and age-related diseases.

Original language	English (US)
Title of host publication	Subcellular Biochemistry
Publisher	Springer New York
Pages	227-247
Number of pages	21
Volume	91
DOIs	https://doi.org/10.1007/978-981-13-3681-2_9
State	Published - Mar 20 2019

Publication series

Name	Sub-cellular biochemistry
Publisher	Plenum Publishers
ISSN (Print)	0306-0225

Bibliographical note

Funding Information:
Acknowledgements This work was supported by the NIH grants P01-AG043376 (PDR, LJN), U19-AG056278 (PDR, LJN, YS) and the Glenn/AFAR (LJN).

Publisher Copyright:
© 2019, Springer Nature Singapore Pte Ltd.

Keywords

Age-related disease
Apoptosis
Inflammation
NF-κB Nrf2
Senescence
Signaling pathways
Sirtuins
Aging/genetics
Humans
Signal Transduction/genetics
Animals
Cellular Senescence
Longevity/genetics
NF-E2-Related Factor 2/metabolism
NF-kappa B/metabolism

PubMed: MeSH publication types

Review
Journal Article

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/978-981-13-3681-2_9

https://link.springer.com/chapter/10.1007/978-981-13-3681-2_9

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Signal transduction, ageing and disease

Abstract

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Bibliographical note

Keywords

PubMed: MeSH publication types

UN SDGs

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