TY - JOUR
T1 - Signal transducer and activator of transcription 5a/b
T2 - Biomarker and therapeutic target in prostate and breast cancer
AU - Koptyra, Mateusz
AU - Gupta, Shilpa
AU - Talati, Pooja
AU - Nevalainen, Marja T.
N1 - Funding Information:
This work was supported by the NIH grant R01-CA113580-01A1 .
PY - 2011/10
Y1 - 2011/10
N2 - The search for new therapeutic strategies for prostate and breast cancer is of significant interest. Signal transducer and activator of transcription 5a/b (Stat5a/b) controls viability and growth of prostate cancer. Nuclear active Stat5a/b expression is clustered to high grade prostate cancers, predicts early disease recurrence and promotes metastatic dissemination of prostate cancer. In breast cancer, the role of Stat5a/b is more complex. In rodent model systems, Stat5a/b may promote malignant transformation and enhance growth of the breast tumors. In contrast, Stat5a/b activation in established human breast cancer positively correlates with tumor differentiation, prevents metastatic dissemination, and predicts favorable clinical outcome of node-negative breast cancer. Here we review the molecular structure and biological functions of Stat5a/b and discuss the potential applications of Stat5a/b for therapy development and as a prognostic marker for prostate and breast cancer.
AB - The search for new therapeutic strategies for prostate and breast cancer is of significant interest. Signal transducer and activator of transcription 5a/b (Stat5a/b) controls viability and growth of prostate cancer. Nuclear active Stat5a/b expression is clustered to high grade prostate cancers, predicts early disease recurrence and promotes metastatic dissemination of prostate cancer. In breast cancer, the role of Stat5a/b is more complex. In rodent model systems, Stat5a/b may promote malignant transformation and enhance growth of the breast tumors. In contrast, Stat5a/b activation in established human breast cancer positively correlates with tumor differentiation, prevents metastatic dissemination, and predicts favorable clinical outcome of node-negative breast cancer. Here we review the molecular structure and biological functions of Stat5a/b and discuss the potential applications of Stat5a/b for therapy development and as a prognostic marker for prostate and breast cancer.
KW - Prostate and breast cancer
KW - Stat5a/b
KW - Therapy and biomarker development
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U2 - 10.1016/j.biocel.2011.06.007
DO - 10.1016/j.biocel.2011.06.007
M3 - Short survey
C2 - 21704724
AN - SCOPUS:80052263093
SN - 1357-2725
VL - 43
SP - 1417
EP - 1421
JO - International Journal of Biochemistry and Cell Biology
JF - International Journal of Biochemistry and Cell Biology
IS - 10
ER -
