Sickle cell trait is not associated with an increased risk of heart failure or abnormalities of cardiac structure and function

Natalie A. Bello, Hyacinth I. Hyacinth, Nicholas S. Roetker, Samantha R. Seals, Rakhi P. Naik, Vimal K. Derebail, Abhijit V. Kshirsagar, Nigel S. Key, James G. Wilson, Adolfo Correa, Robert J. Adams, Leonard D. Egede, W. T. Longstreth, Gaurav Choudhary, Beatrice E. Gee, Austin L. Hughes, Amil M. Shah, Joann E. Manson, Matthew Allison, Gregory L. BurkeAaron R. Folsom, Cara L. Carty, Alexander P. Reiner, Scott D. Solomon, Suma H. Konety

Research output: Contribution to journalLetterpeer-review

12 Scopus citations
Original languageEnglish (US)
Pages (from-to)799-801
Number of pages3
Issue number6
StatePublished - Feb 9 2017

Bibliographical note

Funding Information:
The authors thank the other investigators, staff, and participants of the Atherosclerosis Risk in Communities (ARIC) study, the Multi-Ethnic Study of Atherosclerosis (MESA) study, the Jackson Heart Study (JHS), and the Women's Health Initiative (WHI). The ARIC study is a collaborative study supported by the National Institutes of Health (NIH), National Heart, Lung, and Blood Institute (NHLBI) contracts (HHSN268201100005C, HHSN268201100006C, HHSN268201100007C, HHSN268201100008C, HHSN268201100009C, HHSN268201100010C, HHSN268201100011C, and HHSN268201100012C) and NIH/NHLBI grant 5K12 HL087097-0. MESA and the MESA SNP Health Association Resource (SHARe) projects are conducted and supported by the NIH/NHLBI in collaboration with MESA investigators; MESA is supported by grants from the NIH/NHLBI (HHSN268201500003I, N01-HC-95159, N01-HC-95160, N01-HC-95161, N01-HC-95162, N01-HC-95163, N01-HC-95164, N01-HC-95165, N01-HC-95166, N01-HC-95167, N01-HC-95168, N01-HC-95169, UL1-TR-001079, UL1-TR-000040) and NIH, National Institute of Diabetes and Digestive and Kidney Diseases (DK063491). The JHS is supported by grants from the NIH/NHLBI and the National Institute on Minority Health and Health Disparities (HHSN268201300046C, HHSN268201300047C, HHSN268201300048C, HHSN268201300049C, and HSN268201300050C). The WHI program is funded by the NIH, NIH/NHLBI, and US Department of Health and Human Services through contracts (HHSN268201100046C, HHSN268201100001C, HHSN268201100002C, HHSN268201100003C, HHSN268201100004C, and HHSN271201100004C). This work is supported by grants from NIH/NHLBI (3U01 HL117721 02S2) and an Emory Pediatrics pilot grant (00051285) (H.I.H.); NIH/NHLBI (UO1 HL117659) and the Doris Duke Charitable Foundation (2013123) (N.S.K.); and the NIH/NHLBI (1K08HL125100) (R.P.N.). Full lists of participating investigators and institutions can be found as follows: MESA (, JHS (, and WHI (

Cite this