SHROOM3-FYN Interaction Regulates Nephrin Phosphorylation and Affects Albuminuria in Allografts

J. M. Basgen

Research output: Contribution to journalArticlepeer-review

Abstract

We previously showed that the presence of a CKD-associated locus in SHROOM3 in a donor kidney results in increased expression of SHROOM3 (an F-actin–binding protein important for epithelial morphogenesis, via rho-kinase [ROCK] binding); this facilitates TGF-b signaling and allograft fibrosis. However, other evidence suggests Shroom3 may have a protective role in glomerular development.
Original languageEnglish (US)
JournalJournal of the American Society of Nephrology : JASN
Volume29
Issue number11
DOIs
StatePublished - Oct 31 2018

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