SHROOM3-FYN Interaction Regulates Nephrin Phosphorylation and Affects Albuminuria in Allografts

J. M. Basgen

doi:10.1681/ASN.2018060573

SHROOM3-FYN Interaction Regulates Nephrin Phosphorylation and Affects Albuminuria in Allografts

J. M. Basgen

University Imaging Centers

Research output: Contribution to journal › Article › peer-review

Abstract

We previously showed that the presence of a CKD-associated locus in SHROOM3 in a donor kidney results in increased expression of SHROOM3 (an F-actin–binding protein important for epithelial morphogenesis, via rho-kinase [ROCK] binding); this facilitates TGF-b signaling and allograft fibrosis. However, other evidence suggests Shroom3 may have a protective role in glomerular development.

Original language	English (US)
Journal	Journal of the American Society of Nephrology : JASN
Volume	29
Issue number	11
DOIs	https://doi.org/10.1681/ASN.2018060573
State	Published - Oct 31 2018

Access

10.1681/ASN.2018060573

Fingerprint Dive into the research topics of 'SHROOM3-FYN Interaction Regulates Nephrin Phosphorylation and Affects Albuminuria in Allografts'. Together they form a unique fingerprint.

University Imaging Centers
Mark A Sanders (Program Director) & Guillermo Marques (Scientific Director)
University Imaging Centers
Equipment/facility: Facility

Cite this

@article{9555067e407b41d4a69bcd2febefa01b,

title = "SHROOM3-FYN Interaction Regulates Nephrin Phosphorylation and Affects Albuminuria in Allografts",

abstract = "We previously showed that the presence of a CKD-associated locus in SHROOM3 in a donor kidney results in increased expression of SHROOM3 (an F-actin–binding protein important for epithelial morphogenesis, via rho-kinase [ROCK] binding); this facilitates TGF-b signaling and allograft fibrosis. However, other evidence suggests Shroom3 may have a protective role in glomerular development.",

author = "Basgen, {J. M.}",

year = "2018",

month = oct,

day = "31",

doi = "10.1681/ASN.2018060573",

language = "English (US)",

volume = "29",

journal = "Journal of the American Society of Nephrology",

issn = "1046-6673",

publisher = "American Society of Nephrology",

number = "11",

}

TY - JOUR

T1 - SHROOM3-FYN Interaction Regulates Nephrin Phosphorylation and Affects Albuminuria in Allografts

AU - Basgen, J. M.

PY - 2018/10/31

Y1 - 2018/10/31

N2 - We previously showed that the presence of a CKD-associated locus in SHROOM3 in a donor kidney results in increased expression of SHROOM3 (an F-actin–binding protein important for epithelial morphogenesis, via rho-kinase [ROCK] binding); this facilitates TGF-b signaling and allograft fibrosis. However, other evidence suggests Shroom3 may have a protective role in glomerular development.

AB - We previously showed that the presence of a CKD-associated locus in SHROOM3 in a donor kidney results in increased expression of SHROOM3 (an F-actin–binding protein important for epithelial morphogenesis, via rho-kinase [ROCK] binding); this facilitates TGF-b signaling and allograft fibrosis. However, other evidence suggests Shroom3 may have a protective role in glomerular development.

U2 - 10.1681/ASN.2018060573

DO - 10.1681/ASN.2018060573

M3 - Article

VL - 29

JO - Journal of the American Society of Nephrology

JF - Journal of the American Society of Nephrology

SN - 1046-6673

IS - 11

ER -

SHROOM3-FYN Interaction Regulates Nephrin Phosphorylation and Affects Albuminuria in Allografts

Abstract

Access

University Imaging Centers

Cite this