Shrink-Induced Highly Sensitive Dopamine Sensor Based on Self-Assembly Graphene on Microelectrode

Guihua Xiao; Jungyoon Kim; Xinxia Cai; Tianhong Cui

doi:10.1109/TRANSDUCERS.2019.8808235

Shrink-Induced Highly Sensitive Dopamine Sensor Based on Self-Assembly Graphene on Microelectrode

Guihua Xiao
, Jungyoon Kim
, Xinxia Cai
, Tianhong Cui

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

3 Scopus citations

Abstract

This paper presents a highly sensitive dopamine microelectrode fabricated by self-assembly of graphene on a gold electrode with polystyrene shrink polymer substrate. Nano graphene wrinkles and gaps are formed on the rough gold layer after shrinkage, significantly enhancing the sensor performance for dopamine detection. Compared with the bare gold electrode, the normalized sensitivity of graphene-shrink electrode improved over 130 times from 0.22 nA•μM^-1•mm^-2 to 28.77 nA•μM^-1•mm^-2. The detection limit of dopamine achieved 5 nM, meeting the in-vivo detection requirements. The sensitivity of the shrink electrode increased 23 times from 0.22 nA•μM^-1•mm^-2 to 5.05 nA•μM^-1•mm^-2. This simple dopamine sensor with high sensitivity and low detection limit can be widely used in real-time dopamine recording.

Original language	English (US)
Title of host publication	2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	1120-1123
Number of pages	4
ISBN (Electronic)	9781728120072
DOIs	https://doi.org/10.1109/TRANSDUCERS.2019.8808235
State	Published - Jun 2019
Event	20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII - Berlin, Germany Duration: Jun 23 2019 → Jun 27 2019

Publication series

Name	2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII

Conference

Conference	20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII
Country/Territory	Germany
City	Berlin
Period	6/23/19 → 6/27/19

Bibliographical note

Funding Information:
The authors greatly appreciate the valuable discussion with Professors Zhiyi Sha and Thomas Henry in Medical School and Professor Tay Netoff in Department of Biomedical Engineering at the University of Minnesota. The authors also thank the help from Mr. Peng Zhou for the mask fabrication and Mr. Qingyuan Liu for the sputtering process. The first author acknowledges the support from the joint PhD Training Program from University of Chinese Academy of Sciences.

Publisher Copyright:
© 2019 IEEE.

Keywords

Dopamine
Graphene
High sensitivity
Nano wrinkle
Shrink

Publisher link

10.1109/TRANSDUCERS.2019.8808235

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Cite this

Xiao, G., Kim, J., Cai, X., & Cui, T. (2019). Shrink-Induced Highly Sensitive Dopamine Sensor Based on Self-Assembly Graphene on Microelectrode. In 2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII (pp. 1120-1123). Article 8808235 (2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/TRANSDUCERS.2019.8808235

Shrink-Induced Highly Sensitive Dopamine Sensor Based on Self-Assembly Graphene on Microelectrode. / Xiao, Guihua; Kim, Jungyoon; Cai, Xinxia et al.
2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII. Institute of Electrical and Electronics Engineers Inc., 2019. p. 1120-1123 8808235 (2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Xiao, G, Kim, J, Cai, X & Cui, T 2019, Shrink-Induced Highly Sensitive Dopamine Sensor Based on Self-Assembly Graphene on Microelectrode. in 2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII., 8808235, 2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII, Institute of Electrical and Electronics Engineers Inc., pp. 1120-1123, 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII, Berlin, Germany, 6/23/19. https://doi.org/10.1109/TRANSDUCERS.2019.8808235

Xiao G, Kim J, Cai X, Cui T. Shrink-Induced Highly Sensitive Dopamine Sensor Based on Self-Assembly Graphene on Microelectrode. In 2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII. Institute of Electrical and Electronics Engineers Inc. 2019. p. 1120-1123. 8808235. (2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII). doi: 10.1109/TRANSDUCERS.2019.8808235

Xiao, Guihua ; Kim, Jungyoon ; Cai, Xinxia et al. / Shrink-Induced Highly Sensitive Dopamine Sensor Based on Self-Assembly Graphene on Microelectrode. 2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII. Institute of Electrical and Electronics Engineers Inc., 2019. pp. 1120-1123 (2019 20th International Conference on Solid-State Sensors, Actuators and Microsystems and Eurosensors XXXIII, TRANSDUCERS 2019 and EUROSENSORS XXXIII).

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title = "Shrink-Induced Highly Sensitive Dopamine Sensor Based on Self-Assembly Graphene on Microelectrode",

abstract = "This paper presents a highly sensitive dopamine microelectrode fabricated by self-assembly of graphene on a gold electrode with polystyrene shrink polymer substrate. Nano graphene wrinkles and gaps are formed on the rough gold layer after shrinkage, significantly enhancing the sensor performance for dopamine detection. Compared with the bare gold electrode, the normalized sensitivity of graphene-shrink electrode improved over 130 times from 0.22 nA•μM-1•mm-2 to 28.77 nA•μM-1•mm-2. The detection limit of dopamine achieved 5 nM, meeting the in-vivo detection requirements. The sensitivity of the shrink electrode increased 23 times from 0.22 nA•μM-1•mm-2 to 5.05 nA•μM-1•mm-2. This simple dopamine sensor with high sensitivity and low detection limit can be widely used in real-time dopamine recording.",

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author = "Guihua Xiao and Jungyoon Kim and Xinxia Cai and Tianhong Cui",

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N1 - Funding Information: The authors greatly appreciate the valuable discussion with Professors Zhiyi Sha and Thomas Henry in Medical School and Professor Tay Netoff in Department of Biomedical Engineering at the University of Minnesota. The authors also thank the help from Mr. Peng Zhou for the mask fabrication and Mr. Qingyuan Liu for the sputtering process. The first author acknowledges the support from the joint PhD Training Program from University of Chinese Academy of Sciences. Publisher Copyright: © 2019 IEEE.

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N2 - This paper presents a highly sensitive dopamine microelectrode fabricated by self-assembly of graphene on a gold electrode with polystyrene shrink polymer substrate. Nano graphene wrinkles and gaps are formed on the rough gold layer after shrinkage, significantly enhancing the sensor performance for dopamine detection. Compared with the bare gold electrode, the normalized sensitivity of graphene-shrink electrode improved over 130 times from 0.22 nA•μM-1•mm-2 to 28.77 nA•μM-1•mm-2. The detection limit of dopamine achieved 5 nM, meeting the in-vivo detection requirements. The sensitivity of the shrink electrode increased 23 times from 0.22 nA•μM-1•mm-2 to 5.05 nA•μM-1•mm-2. This simple dopamine sensor with high sensitivity and low detection limit can be widely used in real-time dopamine recording.

AB - This paper presents a highly sensitive dopamine microelectrode fabricated by self-assembly of graphene on a gold electrode with polystyrene shrink polymer substrate. Nano graphene wrinkles and gaps are formed on the rough gold layer after shrinkage, significantly enhancing the sensor performance for dopamine detection. Compared with the bare gold electrode, the normalized sensitivity of graphene-shrink electrode improved over 130 times from 0.22 nA•μM-1•mm-2 to 28.77 nA•μM-1•mm-2. The detection limit of dopamine achieved 5 nM, meeting the in-vivo detection requirements. The sensitivity of the shrink electrode increased 23 times from 0.22 nA•μM-1•mm-2 to 5.05 nA•μM-1•mm-2. This simple dopamine sensor with high sensitivity and low detection limit can be widely used in real-time dopamine recording.

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KW - High sensitivity

KW - Nano wrinkle

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ER -

Shrink-Induced Highly Sensitive Dopamine Sensor Based on Self-Assembly Graphene on Microelectrode

Abstract

Publication series

Conference

Bibliographical note

Keywords

Publisher link

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