Shorter minimum P-wave duration is associated with paroxysmal lone atrial fibrillation

Ian C.Y. Chang, Erin Austin, Balaji Krishnan, David G Benditt, Chwee N. Quay, Lieng H. Ling, Lin Yee Chen

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Background and Purpose Prolonged P-wave dispersion (PWD) and P-wave duration (PWdur) have been found to be associated with common atrial fibrillation (AF), but the association of P-wave indices with lone atrial fibrillation (LAF) is unclear. Methods We enrolled 61 paroxysmal LAF cases and 150 controls without AF. P-wave indices were measured from a 12-lead ECG. Multivariable logistic regression was used to assess the association between P-wave indices and LAF. Results PWD was longer in LAF patients (median, IQR; 54.1 [42.9-63.2] ms) than controls (46.0 [38.5-57.7] ms), P = 0.03. MinPWdur was shorter in LAF patients (60.5 [50.7-72.6] ms) than controls (66.0 [55.5-76.4] ms), P = 0.03. In multivariable models, only the association between shorter minPWdur and LAF remained statistically significant (OR [95% CI] per tertile increment in minPWdur, 0.64 [0.42-0.95], P = 0.03). Conclusions Unlike common AF, paroxysmal LAF is independently associated with shorter minPWdur. This finding suggests that both shorter and prolonged PWdur may be associated with increased risk of AF.

Original languageEnglish (US)
Pages (from-to)106-112
Number of pages7
JournalJournal of Electrocardiology
Issue number1
StatePublished - Jan 2014

Bibliographical note

Funding Information:
This work was supported by the National Medical Research Council of Singapore, Singapore [ NMRC/1141/2007 to L.Y.C].


  • Atrial fibrillation
  • Case-control study
  • Maximum P-wave duration
  • Minimum P-wave duration
  • P-wave dispersion
  • P-wave indices


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