Short-Term Repeatability of Insulin Resistance Indexes in Older Adults

The Atherosclerosis Risk in Communities Study

Anna K. Poon, Michelle L. Meyer, Gerald Reaven, Joshua W. Knowles, Elizabeth Selvin, Jim Pankow, David Couper, Laura Loehr, Gerardo Heiss

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Context The homeostatic model assessment of insulin resistance (HOMA-IR) and triglyceride (TG)/high-density lipoprotein cholesterol (HDL-C) ratio (TG/HDL-C) are insulin resistance indexes routinely used in clinical and population-based studies; however, their short-term repeatability is not well characterized. Objective To quantify the short-term repeatability of insulin resistance indexes and their analytes, consisting of fasting glucose and insulin for HOMA-IR and TG and HDL-C for TG/HDL-C. Design Prospective cohort study. Participants A total of 102 adults 68 to 88 years old without diabetes attended an initial examination and repeated examination (mean, 46 days; range, 28 to 102 days). Blood samples were collected, processed, shipped, and assayed following a standardized protocol. Main Outcome Measures Repeatability was quantified using the intraclass correlation coefficient (ICC) and within-person coefficient of variation (CV). Minimum detectable change (MDC 95) and minimum detectable difference with 95% confidence (MDD 95) were quantified. Results For HOMA-IR, insulin, and fasting glucose, the ICCs were 0.70, 0.68, and 0.70, respectively; their respective within-person CVs were 30.4%, 28.8%, and 5.6%. For TG/HDL-C, TG, and HDL-C, the ICCs were 0.80, 0.68, and 0.91, respectively; their respective within-person CVs were 23.0%, 20.6%, and 8.2%. The MDC 95 was 2.3 for HOMA-IR and 1.4 for TG/HDL-C. The MDD 95 for a sample of n = 100 was 0.8 for HOMA-IR and 0.6 for TG/HDL-C. Conclusions Short-term repeatability was fair to good for HOMA-IR and excellent for TG/HDL-C according to suggested benchmarks, reflecting the short-term variability of their analytes. These measurement properties can inform the use of these indexes in clinical and population-based studies.

Original languageEnglish (US)
Pages (from-to)2175-2181
Number of pages7
JournalJournal of Clinical Endocrinology and Metabolism
Volume103
Issue number6
DOIs
StatePublished - Jun 1 2018

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Insulin Resistance
Atherosclerosis
Triglycerides
Insulin
HDL Cholesterol
Fasting
Glucose
Benchmarking
Medical problems
Population
Cohort Studies
Outcome Assessment (Health Care)
Blood
Prospective Studies

Cite this

Short-Term Repeatability of Insulin Resistance Indexes in Older Adults : The Atherosclerosis Risk in Communities Study. / Poon, Anna K.; Meyer, Michelle L.; Reaven, Gerald; Knowles, Joshua W.; Selvin, Elizabeth; Pankow, Jim; Couper, David; Loehr, Laura; Heiss, Gerardo.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 103, No. 6, 01.06.2018, p. 2175-2181.

Research output: Contribution to journalArticle

Poon, Anna K. ; Meyer, Michelle L. ; Reaven, Gerald ; Knowles, Joshua W. ; Selvin, Elizabeth ; Pankow, Jim ; Couper, David ; Loehr, Laura ; Heiss, Gerardo. / Short-Term Repeatability of Insulin Resistance Indexes in Older Adults : The Atherosclerosis Risk in Communities Study. In: Journal of Clinical Endocrinology and Metabolism. 2018 ; Vol. 103, No. 6. pp. 2175-2181.
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abstract = "Context The homeostatic model assessment of insulin resistance (HOMA-IR) and triglyceride (TG)/high-density lipoprotein cholesterol (HDL-C) ratio (TG/HDL-C) are insulin resistance indexes routinely used in clinical and population-based studies; however, their short-term repeatability is not well characterized. Objective To quantify the short-term repeatability of insulin resistance indexes and their analytes, consisting of fasting glucose and insulin for HOMA-IR and TG and HDL-C for TG/HDL-C. Design Prospective cohort study. Participants A total of 102 adults 68 to 88 years old without diabetes attended an initial examination and repeated examination (mean, 46 days; range, 28 to 102 days). Blood samples were collected, processed, shipped, and assayed following a standardized protocol. Main Outcome Measures Repeatability was quantified using the intraclass correlation coefficient (ICC) and within-person coefficient of variation (CV). Minimum detectable change (MDC 95) and minimum detectable difference with 95{\%} confidence (MDD 95) were quantified. Results For HOMA-IR, insulin, and fasting glucose, the ICCs were 0.70, 0.68, and 0.70, respectively; their respective within-person CVs were 30.4{\%}, 28.8{\%}, and 5.6{\%}. For TG/HDL-C, TG, and HDL-C, the ICCs were 0.80, 0.68, and 0.91, respectively; their respective within-person CVs were 23.0{\%}, 20.6{\%}, and 8.2{\%}. The MDC 95 was 2.3 for HOMA-IR and 1.4 for TG/HDL-C. The MDD 95 for a sample of n = 100 was 0.8 for HOMA-IR and 0.6 for TG/HDL-C. Conclusions Short-term repeatability was fair to good for HOMA-IR and excellent for TG/HDL-C according to suggested benchmarks, reflecting the short-term variability of their analytes. These measurement properties can inform the use of these indexes in clinical and population-based studies.",
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T1 - Short-Term Repeatability of Insulin Resistance Indexes in Older Adults

T2 - The Atherosclerosis Risk in Communities Study

AU - Poon, Anna K.

AU - Meyer, Michelle L.

AU - Reaven, Gerald

AU - Knowles, Joshua W.

AU - Selvin, Elizabeth

AU - Pankow, Jim

AU - Couper, David

AU - Loehr, Laura

AU - Heiss, Gerardo

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N2 - Context The homeostatic model assessment of insulin resistance (HOMA-IR) and triglyceride (TG)/high-density lipoprotein cholesterol (HDL-C) ratio (TG/HDL-C) are insulin resistance indexes routinely used in clinical and population-based studies; however, their short-term repeatability is not well characterized. Objective To quantify the short-term repeatability of insulin resistance indexes and their analytes, consisting of fasting glucose and insulin for HOMA-IR and TG and HDL-C for TG/HDL-C. Design Prospective cohort study. Participants A total of 102 adults 68 to 88 years old without diabetes attended an initial examination and repeated examination (mean, 46 days; range, 28 to 102 days). Blood samples were collected, processed, shipped, and assayed following a standardized protocol. Main Outcome Measures Repeatability was quantified using the intraclass correlation coefficient (ICC) and within-person coefficient of variation (CV). Minimum detectable change (MDC 95) and minimum detectable difference with 95% confidence (MDD 95) were quantified. Results For HOMA-IR, insulin, and fasting glucose, the ICCs were 0.70, 0.68, and 0.70, respectively; their respective within-person CVs were 30.4%, 28.8%, and 5.6%. For TG/HDL-C, TG, and HDL-C, the ICCs were 0.80, 0.68, and 0.91, respectively; their respective within-person CVs were 23.0%, 20.6%, and 8.2%. The MDC 95 was 2.3 for HOMA-IR and 1.4 for TG/HDL-C. The MDD 95 for a sample of n = 100 was 0.8 for HOMA-IR and 0.6 for TG/HDL-C. Conclusions Short-term repeatability was fair to good for HOMA-IR and excellent for TG/HDL-C according to suggested benchmarks, reflecting the short-term variability of their analytes. These measurement properties can inform the use of these indexes in clinical and population-based studies.

AB - Context The homeostatic model assessment of insulin resistance (HOMA-IR) and triglyceride (TG)/high-density lipoprotein cholesterol (HDL-C) ratio (TG/HDL-C) are insulin resistance indexes routinely used in clinical and population-based studies; however, their short-term repeatability is not well characterized. Objective To quantify the short-term repeatability of insulin resistance indexes and their analytes, consisting of fasting glucose and insulin for HOMA-IR and TG and HDL-C for TG/HDL-C. Design Prospective cohort study. Participants A total of 102 adults 68 to 88 years old without diabetes attended an initial examination and repeated examination (mean, 46 days; range, 28 to 102 days). Blood samples were collected, processed, shipped, and assayed following a standardized protocol. Main Outcome Measures Repeatability was quantified using the intraclass correlation coefficient (ICC) and within-person coefficient of variation (CV). Minimum detectable change (MDC 95) and minimum detectable difference with 95% confidence (MDD 95) were quantified. Results For HOMA-IR, insulin, and fasting glucose, the ICCs were 0.70, 0.68, and 0.70, respectively; their respective within-person CVs were 30.4%, 28.8%, and 5.6%. For TG/HDL-C, TG, and HDL-C, the ICCs were 0.80, 0.68, and 0.91, respectively; their respective within-person CVs were 23.0%, 20.6%, and 8.2%. The MDC 95 was 2.3 for HOMA-IR and 1.4 for TG/HDL-C. The MDD 95 for a sample of n = 100 was 0.8 for HOMA-IR and 0.6 for TG/HDL-C. Conclusions Short-term repeatability was fair to good for HOMA-IR and excellent for TG/HDL-C according to suggested benchmarks, reflecting the short-term variability of their analytes. These measurement properties can inform the use of these indexes in clinical and population-based studies.

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