Short-term regulation of muscarinic acetylcholine receptor binding in cultured nerve cells

P. Feigenbaum; E. E. El-Fakahany

Short-term regulation of muscarinic acetylcholine receptor binding in cultured nerve cells

P. Feigenbaum, E. E. El-Fakahany

Pharmacy Research and Graduate Education

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Short-term preincubation of mouse neuroblastoma cells (clone N1E-115) with the muscarinic agonist carbamylcholine at 37°C resulted in a significant decrease in the binding of the muscarinic antagonist [³H]N-methylscopolamine. This agonist-induced response reached a steady state at 30 min. It was also dose dependent, saturable and sensitive to temperature, suggesting a receptor-mediated phenomenon. The significance of these findings is discussed.

Original language	English (US)
Pages (from-to)	519-522
Number of pages	4
Journal	Research Communications in Chemical Pathology and Pharmacology
Volume	43
Issue number	3
State	Published - Jan 1 1984

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abstract = "Short-term preincubation of mouse neuroblastoma cells (clone N1E-115) with the muscarinic agonist carbamylcholine at 37°C resulted in a significant decrease in the binding of the muscarinic antagonist [3H]N-methylscopolamine. This agonist-induced response reached a steady state at 30 min. It was also dose dependent, saturable and sensitive to temperature, suggesting a receptor-mediated phenomenon. The significance of these findings is discussed.",

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N2 - Short-term preincubation of mouse neuroblastoma cells (clone N1E-115) with the muscarinic agonist carbamylcholine at 37°C resulted in a significant decrease in the binding of the muscarinic antagonist [3H]N-methylscopolamine. This agonist-induced response reached a steady state at 30 min. It was also dose dependent, saturable and sensitive to temperature, suggesting a receptor-mediated phenomenon. The significance of these findings is discussed.

AB - Short-term preincubation of mouse neuroblastoma cells (clone N1E-115) with the muscarinic agonist carbamylcholine at 37°C resulted in a significant decrease in the binding of the muscarinic antagonist [3H]N-methylscopolamine. This agonist-induced response reached a steady state at 30 min. It was also dose dependent, saturable and sensitive to temperature, suggesting a receptor-mediated phenomenon. The significance of these findings is discussed.

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ER -

Short-term regulation of muscarinic acetylcholine receptor binding in cultured nerve cells

Abstract

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