TY - JOUR
T1 - Short Physical Performance Battery and all-cause mortality
T2 - Systematic review and meta-analysis
AU - Pavasini, Rita
AU - Guralnik, Jack
AU - Brown, Justin C.
AU - di Bari, Mauro
AU - Cesari, Matteo
AU - Landi, Francesco
AU - Vaes, Bert
AU - Legrand, Delphine
AU - Verghese, Joe
AU - Wang, Cuiling
AU - Stenholm, Sari
AU - Ferrucci, Luigi
AU - Lai, Jennifer C.
AU - Bartes, Anna Arnau
AU - Espaulella, Joan
AU - Ferrer, Montserrat
AU - Lim, Jae Young
AU - Ensrud, Kristine E.
AU - Cawthon, Peggy
AU - Turusheva, Anna
AU - Frolova, Elena
AU - Rolland, Yves
AU - Lauwers, Valerie
AU - Corsonello, Andrea
AU - Kirk, Gregory D.
AU - Ferrari, Roberto
AU - Volpato, Stefano
AU - Campo, Gianluca
N1 - Publisher Copyright:
© 2016 The Author(s).
PY - 2016/12/22
Y1 - 2016/12/22
N2 - Background: The Short Physical Performance Battery (SPPB) is a well-established tool to assess lower extremity physical performance status. Its predictive ability for all-cause mortality has been sparsely reported, but with conflicting results in different subsets of participants. The aim of this study was to perform a meta-analysis investigating the relationship between SPPB score and all-cause mortality. Methods: Articles were searched in MEDLINE, the Cochrane Library, Google Scholar, and BioMed Central between July and September 2015 and updated in January 2016. Inclusion criteria were observational studies; >50 participants; stratification of population according to SPPB value; data on all-cause mortality; English language publications. Twenty-four articles were selected from available evidence. Data of interest (i.e., clinical characteristics, information after stratification of the sample into four SPPB groups [0-3, 4-6, 7-9, 10-12]) were retrieved from the articles and/or obtained by the study authors. The odds ratio (OR) and/or hazard ratio (HR) was obtained for all-cause mortality according to SPPB category (with SPPB scores 10-12 considered as reference) with adjustment for age, sex, and body mass index. Results: Standardized data were obtained for 17 studies (n=16,534, mean age 76±3years). As compared to SPPB scores 10-12, values of 0-3 (OR 3.25, 95%CI 2.86-3.79), 4-6 (OR 2.14, 95%CI 1.92-2.39), and 7-9 (OR 1.50, 95%CI 1.32-1.71) were each associated with an increased risk of all-cause mortality. The association between poor performance on SPPB and all-cause mortality remained highly consistent independent of follow-up length, subsets of participants, geographic area, and age of the population. Random effects meta-regression showed that OR for all-cause mortality with SPPB values 7-9 was higher in the younger population, diabetics, and men. Conclusions: An SPPB score lower than 10 is predictive of all-cause mortality. The systematic implementation of the SPPB in clinical practice settings may provide useful prognostic information about the risk of all-cause mortality. Moreover, the SPPB could be used as a surrogate endpoint of all-cause mortality in trials needing to quantify benefit and health improvements of specific treatments or rehabilitation programs. The study protocol was published on PROSPERO (CRD42015024916).
AB - Background: The Short Physical Performance Battery (SPPB) is a well-established tool to assess lower extremity physical performance status. Its predictive ability for all-cause mortality has been sparsely reported, but with conflicting results in different subsets of participants. The aim of this study was to perform a meta-analysis investigating the relationship between SPPB score and all-cause mortality. Methods: Articles were searched in MEDLINE, the Cochrane Library, Google Scholar, and BioMed Central between July and September 2015 and updated in January 2016. Inclusion criteria were observational studies; >50 participants; stratification of population according to SPPB value; data on all-cause mortality; English language publications. Twenty-four articles were selected from available evidence. Data of interest (i.e., clinical characteristics, information after stratification of the sample into four SPPB groups [0-3, 4-6, 7-9, 10-12]) were retrieved from the articles and/or obtained by the study authors. The odds ratio (OR) and/or hazard ratio (HR) was obtained for all-cause mortality according to SPPB category (with SPPB scores 10-12 considered as reference) with adjustment for age, sex, and body mass index. Results: Standardized data were obtained for 17 studies (n=16,534, mean age 76±3years). As compared to SPPB scores 10-12, values of 0-3 (OR 3.25, 95%CI 2.86-3.79), 4-6 (OR 2.14, 95%CI 1.92-2.39), and 7-9 (OR 1.50, 95%CI 1.32-1.71) were each associated with an increased risk of all-cause mortality. The association between poor performance on SPPB and all-cause mortality remained highly consistent independent of follow-up length, subsets of participants, geographic area, and age of the population. Random effects meta-regression showed that OR for all-cause mortality with SPPB values 7-9 was higher in the younger population, diabetics, and men. Conclusions: An SPPB score lower than 10 is predictive of all-cause mortality. The systematic implementation of the SPPB in clinical practice settings may provide useful prognostic information about the risk of all-cause mortality. Moreover, the SPPB could be used as a surrogate endpoint of all-cause mortality in trials needing to quantify benefit and health improvements of specific treatments or rehabilitation programs. The study protocol was published on PROSPERO (CRD42015024916).
KW - All-cause mortality
KW - Meta-analysis
KW - Physical function
KW - Short Physical Performance Battery
UR - http://www.scopus.com/inward/record.url?scp=85006786203&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85006786203&partnerID=8YFLogxK
U2 - 10.1186/s12916-016-0763-7
DO - 10.1186/s12916-016-0763-7
M3 - Article
C2 - 28003033
AN - SCOPUS:85006786203
SN - 1741-7015
VL - 14
JO - BMC medicine
JF - BMC medicine
IS - 1
M1 - 215
ER -