Short communication: HIV type 1 escapes inactivation by saliva via rapid escape into oral epithelial cells

Elizabeth A. Dietrich, Kristin H. Gebhard, Claudine E. Fasching, Rodrigo A. Giacaman, John C. Kappes, Karen F Ross, Mark C Herzberg

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Saliva contains anti-HIV-1 factors, which show unclear efficacy in thwarting mucosal infection. When incubated in fresh, unfractionated whole saliva, infectious HIV-1 IIIb and BaL (X4- and R5-tropic, respectively) persisted from 4 to at least 30min in a saliva concentration-dependent manner. In salivary supernatant for up to 6h, both infectious HIV-1 strains "escaped" into immortalized oral epithelial cells; infectious BaL showed selectively enhanced escape in the presence of saliva. Fluorescently labeled HIV-1 virus-like particles entered oral epithelial cells within minutes of exposure. Using a previously unrecognized mechanism, therefore, strains of HIV-1 escape inactivation by saliva via rapid uptake into oral epithelial cells.

Original languageEnglish (US)
Pages (from-to)1574-1578
Number of pages5
JournalAIDS Research and Human Retroviruses
Volume28
Issue number12
DOIs
StatePublished - Dec 1 2012

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