Short and practical enantioselective synthesis of linezolid and eperezolid via proline-catalyzed asymmetric α-aminooxylation

Srinivasarao V. Narina; Arumugam Sudalai

doi:10.1016/j.tetlet.2006.07.065

Short and practical enantioselective synthesis of linezolid and eperezolid via proline-catalyzed asymmetric α-aminooxylation

Srinivasarao V. Narina, Arumugam Sudalai

Chemistry (Twin Cities)

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

An efficient enantioselective synthesis of the antibacterials, linezolid (U-100766), and eperezolid (U-100592) using d-proline-catalyzed asymmetric α-aminooxylation of aldehydes as the key step is described here. This is the first report on the enantioselective synthesis of linezolid and eperezolid using asymmetric catalysis.

Original language	English (US)
Pages (from-to)	6799-6802
Number of pages	4
Journal	Tetrahedron Letters
Volume	47
Issue number	38
DOIs	https://doi.org/10.1016/j.tetlet.2006.07.065
State	Published - Sep 18 2006

Bibliographical note

Funding Information:
N.V.S.R. thanks CSIR, New Delhi, for the award of research fellowships. The authors are thankful to Dr. B. D. Kulkarni, Head, CEPD, for his support and encouragement.

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title = "Short and practical enantioselective synthesis of linezolid and eperezolid via proline-catalyzed asymmetric α-aminooxylation",

abstract = "An efficient enantioselective synthesis of the antibacterials, linezolid (U-100766), and eperezolid (U-100592) using d-proline-catalyzed asymmetric α-aminooxylation of aldehydes as the key step is described here. This is the first report on the enantioselective synthesis of linezolid and eperezolid using asymmetric catalysis.",

author = "Narina, {Srinivasarao V.} and Arumugam Sudalai",

note = "Funding Information: N.V.S.R. thanks CSIR, New Delhi, for the award of research fellowships. The authors are thankful to Dr. B. D. Kulkarni, Head, CEPD, for his support and encouragement.",

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doi = "10.1016/j.tetlet.2006.07.065",

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T1 - Short and practical enantioselective synthesis of linezolid and eperezolid via proline-catalyzed asymmetric α-aminooxylation

AU - Narina, Srinivasarao V.

AU - Sudalai, Arumugam

N1 - Funding Information: N.V.S.R. thanks CSIR, New Delhi, for the award of research fellowships. The authors are thankful to Dr. B. D. Kulkarni, Head, CEPD, for his support and encouragement.

PY - 2006/9/18

Y1 - 2006/9/18

N2 - An efficient enantioselective synthesis of the antibacterials, linezolid (U-100766), and eperezolid (U-100592) using d-proline-catalyzed asymmetric α-aminooxylation of aldehydes as the key step is described here. This is the first report on the enantioselective synthesis of linezolid and eperezolid using asymmetric catalysis.

AB - An efficient enantioselective synthesis of the antibacterials, linezolid (U-100766), and eperezolid (U-100592) using d-proline-catalyzed asymmetric α-aminooxylation of aldehydes as the key step is described here. This is the first report on the enantioselective synthesis of linezolid and eperezolid using asymmetric catalysis.

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DO - 10.1016/j.tetlet.2006.07.065

M3 - Article

AN - SCOPUS:33747156375

VL - 47

SP - 6799

EP - 6802

JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

IS - 38

ER -

Short and practical enantioselective synthesis of linezolid and eperezolid via proline-catalyzed asymmetric α-aminooxylation

Abstract

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