Short and practical enantioselective synthesis of linezolid and eperezolid via proline-catalyzed asymmetric α-aminooxylation

Srinivasarao V. Narina, Arumugam Sudalai

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

An efficient enantioselective synthesis of the antibacterials, linezolid (U-100766), and eperezolid (U-100592) using d-proline-catalyzed asymmetric α-aminooxylation of aldehydes as the key step is described here. This is the first report on the enantioselective synthesis of linezolid and eperezolid using asymmetric catalysis.

Original languageEnglish (US)
Pages (from-to)6799-6802
Number of pages4
JournalTetrahedron Letters
Volume47
Issue number38
DOIs
StatePublished - Sep 18 2006

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