Abstract
An efficient enantioselective synthesis of the antibacterials, linezolid (U-100766), and eperezolid (U-100592) using d-proline-catalyzed asymmetric α-aminooxylation of aldehydes as the key step is described here. This is the first report on the enantioselective synthesis of linezolid and eperezolid using asymmetric catalysis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 6799-6802 |
| Number of pages | 4 |
| Journal | Tetrahedron Letters |
| Volume | 47 |
| Issue number | 38 |
| DOIs | |
| State | Published - Sep 18 2006 |
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Narina, S. V., & Sudalai, A. (2006). Short and practical enantioselective synthesis of linezolid and eperezolid via proline-catalyzed asymmetric α-aminooxylation. Tetrahedron Letters, 47(38), 6799-6802. https://doi.org/10.1016/j.tetlet.2006.07.065