Sexual Health Behaviors by Age 17 and Lower Urinary Tract Symptoms at Age 19: PLUS Research Consortium Analysis of ALSPAC Data

Deepa R. Camenga; Zhenxun Wang; Haitao Chu; Sarah Lindberg; Siobhan Sutcliffe; Sonya S. Brady; Tamera Coyne-Beasley; Colleen M. Fitzgerald; Sheila Gahagan; Lisa Kane Low; D. Yvette LaCoursiere; Missy Lavender; Ariana L. Smith; Ann Stapleton; Bernard L. Harlow

doi:10.1016/j.jadohealth.2022.12.019

Sexual Health Behaviors by Age 17 and Lower Urinary Tract Symptoms at Age 19: PLUS Research Consortium Analysis of ALSPAC Data

Deepa R. Camenga, Zhenxun Wang, Haitao Chu, Sarah Lindberg, Siobhan Sutcliffe, Sonya S. Brady, Tamera Coyne-Beasley, Colleen M. Fitzgerald, Sheila Gahagan, Lisa Kane Low, D. Yvette LaCoursiere, Missy Lavender, Ariana L. Smith, Ann Stapleton, Bernard L. Harlow

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Purpose: We examined how antecedent sexual health factors affect lower urinary tract symptoms (LUTS) in adolescent women. Methods: We analyzed 1,941 adolescent women from the Avon Longitudinal Study of Parents and Children at age 19. At ages 15 and 17, participants reported use of oral contraceptives (OCs), history of sexual intercourse, number of sexual partners, and condom use. At age 19, The Bristol Female Lower Urinary Tract Symptoms questionnaire quantified the frequency over the past month: stress incontinence, any incontinence, urgency, sensation of incomplete emptying, bladder pain, and urinary tract infection. Multivariable regression models examined associations between sexual health behaviors reported at ages 15 and 17 and six LUTS reported at age 19, after controlling for covariates. Results: Commonly reported LUTS at age 19 were past-month stress incontinence (26.8%), bladder pain (26.3%), any urine leakage (22.1%), and urinary tract infection (15.4%). OC use by age 17 was associated with urgency (odds ratio [OR] = 1.62, 95% confidence interval [CI] 1.19–2.20), incomplete emptying (OR = 1.62, 95% CI = 1.17–2.26), bladder pain (OR = 1.45, 95% CI = 1.15–1.83), and urinary tract infections (OR = 1.68, 95% CI = 1.28–2.21) at age 19 after adjustment for covariates. However, associations were attenuated after adjustment for condom use and number of sexual partners. Sexual intercourse by age 17 was associated with 1.53–2.65 increased odds of LUTs categories except incontinence, with lower confidence interval boundaries > 1.0. Associations were stronger among women with ≥ 3 sexual partners (vs. 0) by age 17. Discussion: We found longitudinally assessed associations between OC use, sexual intercourse, and number of sexual partners during adolescence and LUTS at age 19.

Original language	English (US)
Pages (from-to)	737-745
Number of pages	9
Journal	Journal of Adolescent Health
Volume	72
Issue number	5
DOIs	https://doi.org/10.1016/j.jadohealth.2022.12.019
State	Published - May 2023

Bibliographical note

Funding Information:
The Prevention of Lower Urinary Tract Symptoms (PLUS) Research Consortium is supported by the National Institutes of Health (NIH) through cooperative agreements (grants U01DK106786 , U01DK106853 , U01DK106858 , U01DK106898 , U01DK106893 , U01DK106827 , U01DK106908 , U01DK106892 ). Additional support is provided by the National Institute on Aging , NIH Office of Research on Women's Health , and NIH Office of Behavioral and Social Sciences Research . The content of this article is solely the responsibility of the authors and does not necessarily represent the official views of NIH. The UK Medical Research Council and Wellcome (Grant ref: 217065/Z/19/Z) and the University of Bristol provide core support for ALSPAC. This publication is the work of the authors who will serve as guarantors for the contents of this article. A comprehensive list of grants funding is available on the ALSPAC website ( http://www.bristol.ac.uk/alspac/external/documents/grant-acknowledgements.pdf ); These data collected for this research were specifically funded by the Wellcome Trust and MRC (Core) 76467/Z/05/Z & 86676/Z/08/Z, MRC G0701503/85179, and the International Urogynecological Association. Please note that the ALPSAC study website contains details of all the data that are available through a fully searchable data dictionary and variable search tool: http://www.bristol.ac.uk/alspac/researchers/our-data/ .

Publisher Copyright:
© 2023 Society for Adolescent Health and Medicine

Keywords

ALSPAC
Adolescent women
Epidemiology
Lower urinary tract symptoms
Sexual history

PubMed: MeSH publication types

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Publisher link

10.1016/j.jadohealth.2022.12.019

Find It

Find It at U of M Libraries

Cite this

Camenga, D. R., Wang, Z., Chu, H., Lindberg, S., Sutcliffe, S., Brady, S. S., Coyne-Beasley, T., Fitzgerald, C. M., Gahagan, S., Low, L. K., LaCoursiere, D. Y., Lavender, M., Smith, A. L., Stapleton, A., & Harlow, B. L. (2023). Sexual Health Behaviors by Age 17 and Lower Urinary Tract Symptoms at Age 19: PLUS Research Consortium Analysis of ALSPAC Data. Journal of Adolescent Health, 72(5), 737-745. https://doi.org/10.1016/j.jadohealth.2022.12.019

Camenga, DR, Wang, Z, Chu, H, Lindberg, S, Sutcliffe, S, Brady, SS, Coyne-Beasley, T, Fitzgerald, CM, Gahagan, S, Low, LK, LaCoursiere, DY, Lavender, M, Smith, AL, Stapleton, A & Harlow, BL 2023, 'Sexual Health Behaviors by Age 17 and Lower Urinary Tract Symptoms at Age 19: PLUS Research Consortium Analysis of ALSPAC Data', Journal of Adolescent Health, vol. 72, no. 5, pp. 737-745. https://doi.org/10.1016/j.jadohealth.2022.12.019

@article{172c2786bd2c49a58aef763ccff8ef73,

title = "Sexual Health Behaviors by Age 17 and Lower Urinary Tract Symptoms at Age 19: PLUS Research Consortium Analysis of ALSPAC Data",

abstract = "Purpose: We examined how antecedent sexual health factors affect lower urinary tract symptoms (LUTS) in adolescent women. Methods: We analyzed 1,941 adolescent women from the Avon Longitudinal Study of Parents and Children at age 19. At ages 15 and 17, participants reported use of oral contraceptives (OCs), history of sexual intercourse, number of sexual partners, and condom use. At age 19, The Bristol Female Lower Urinary Tract Symptoms questionnaire quantified the frequency over the past month: stress incontinence, any incontinence, urgency, sensation of incomplete emptying, bladder pain, and urinary tract infection. Multivariable regression models examined associations between sexual health behaviors reported at ages 15 and 17 and six LUTS reported at age 19, after controlling for covariates. Results: Commonly reported LUTS at age 19 were past-month stress incontinence (26.8%), bladder pain (26.3%), any urine leakage (22.1%), and urinary tract infection (15.4%). OC use by age 17 was associated with urgency (odds ratio [OR] = 1.62, 95% confidence interval [CI] 1.19–2.20), incomplete emptying (OR = 1.62, 95% CI = 1.17–2.26), bladder pain (OR = 1.45, 95% CI = 1.15–1.83), and urinary tract infections (OR = 1.68, 95% CI = 1.28–2.21) at age 19 after adjustment for covariates. However, associations were attenuated after adjustment for condom use and number of sexual partners. Sexual intercourse by age 17 was associated with 1.53–2.65 increased odds of LUTs categories except incontinence, with lower confidence interval boundaries > 1.0. Associations were stronger among women with ≥ 3 sexual partners (vs. 0) by age 17. Discussion: We found longitudinally assessed associations between OC use, sexual intercourse, and number of sexual partners during adolescence and LUTS at age 19.",

keywords = "ALSPAC, Adolescent women, Epidemiology, Lower urinary tract symptoms, Sexual history",

author = "Camenga, {Deepa R.} and Zhenxun Wang and Haitao Chu and Sarah Lindberg and Siobhan Sutcliffe and Brady, {Sonya S.} and Tamera Coyne-Beasley and Fitzgerald, {Colleen M.} and Sheila Gahagan and Low, {Lisa Kane} and LaCoursiere, {D. Yvette} and Missy Lavender and Smith, {Ariana L.} and Ann Stapleton and Harlow, {Bernard L.}",

note = "Funding Information: The Prevention of Lower Urinary Tract Symptoms (PLUS) Research Consortium is supported by the National Institutes of Health (NIH) through cooperative agreements (grants U01DK106786 , U01DK106853 , U01DK106858 , U01DK106898 , U01DK106893 , U01DK106827 , U01DK106908 , U01DK106892 ). Additional support is provided by the National Institute on Aging , NIH Office of Research on Women's Health , and NIH Office of Behavioral and Social Sciences Research . The content of this article is solely the responsibility of the authors and does not necessarily represent the official views of NIH. The UK Medical Research Council and Wellcome (Grant ref: 217065/Z/19/Z) and the University of Bristol provide core support for ALSPAC. This publication is the work of the authors who will serve as guarantors for the contents of this article. A comprehensive list of grants funding is available on the ALSPAC website ( http://www.bristol.ac.uk/alspac/external/documents/grant-acknowledgements.pdf ); These data collected for this research were specifically funded by the Wellcome Trust and MRC (Core) 76467/Z/05/Z & 86676/Z/08/Z, MRC G0701503/85179, and the International Urogynecological Association. Please note that the ALPSAC study website contains details of all the data that are available through a fully searchable data dictionary and variable search tool: http://www.bristol.ac.uk/alspac/researchers/our-data/ . Publisher Copyright: {\textcopyright} 2023 Society for Adolescent Health and Medicine",

year = "2023",

month = may,

doi = "10.1016/j.jadohealth.2022.12.019",

language = "English (US)",

volume = "72",

pages = "737--745",

journal = "Journal of Adolescent Health",

issn = "1054-139X",

publisher = "Elsevier USA",

number = "5",

}

TY - JOUR

T1 - Sexual Health Behaviors by Age 17 and Lower Urinary Tract Symptoms at Age 19

T2 - PLUS Research Consortium Analysis of ALSPAC Data

AU - Camenga, Deepa R.

AU - Wang, Zhenxun

AU - Chu, Haitao

AU - Lindberg, Sarah

AU - Sutcliffe, Siobhan

AU - Brady, Sonya S.

AU - Coyne-Beasley, Tamera

AU - Fitzgerald, Colleen M.

AU - Gahagan, Sheila

AU - Low, Lisa Kane

AU - LaCoursiere, D. Yvette

AU - Lavender, Missy

AU - Smith, Ariana L.

AU - Stapleton, Ann

AU - Harlow, Bernard L.

N1 - Funding Information: The Prevention of Lower Urinary Tract Symptoms (PLUS) Research Consortium is supported by the National Institutes of Health (NIH) through cooperative agreements (grants U01DK106786 , U01DK106853 , U01DK106858 , U01DK106898 , U01DK106893 , U01DK106827 , U01DK106908 , U01DK106892 ). Additional support is provided by the National Institute on Aging , NIH Office of Research on Women's Health , and NIH Office of Behavioral and Social Sciences Research . The content of this article is solely the responsibility of the authors and does not necessarily represent the official views of NIH. The UK Medical Research Council and Wellcome (Grant ref: 217065/Z/19/Z) and the University of Bristol provide core support for ALSPAC. This publication is the work of the authors who will serve as guarantors for the contents of this article. A comprehensive list of grants funding is available on the ALSPAC website ( http://www.bristol.ac.uk/alspac/external/documents/grant-acknowledgements.pdf ); These data collected for this research were specifically funded by the Wellcome Trust and MRC (Core) 76467/Z/05/Z & 86676/Z/08/Z, MRC G0701503/85179, and the International Urogynecological Association. Please note that the ALPSAC study website contains details of all the data that are available through a fully searchable data dictionary and variable search tool: http://www.bristol.ac.uk/alspac/researchers/our-data/ . Publisher Copyright: © 2023 Society for Adolescent Health and Medicine

PY - 2023/5

Y1 - 2023/5

N2 - Purpose: We examined how antecedent sexual health factors affect lower urinary tract symptoms (LUTS) in adolescent women. Methods: We analyzed 1,941 adolescent women from the Avon Longitudinal Study of Parents and Children at age 19. At ages 15 and 17, participants reported use of oral contraceptives (OCs), history of sexual intercourse, number of sexual partners, and condom use. At age 19, The Bristol Female Lower Urinary Tract Symptoms questionnaire quantified the frequency over the past month: stress incontinence, any incontinence, urgency, sensation of incomplete emptying, bladder pain, and urinary tract infection. Multivariable regression models examined associations between sexual health behaviors reported at ages 15 and 17 and six LUTS reported at age 19, after controlling for covariates. Results: Commonly reported LUTS at age 19 were past-month stress incontinence (26.8%), bladder pain (26.3%), any urine leakage (22.1%), and urinary tract infection (15.4%). OC use by age 17 was associated with urgency (odds ratio [OR] = 1.62, 95% confidence interval [CI] 1.19–2.20), incomplete emptying (OR = 1.62, 95% CI = 1.17–2.26), bladder pain (OR = 1.45, 95% CI = 1.15–1.83), and urinary tract infections (OR = 1.68, 95% CI = 1.28–2.21) at age 19 after adjustment for covariates. However, associations were attenuated after adjustment for condom use and number of sexual partners. Sexual intercourse by age 17 was associated with 1.53–2.65 increased odds of LUTs categories except incontinence, with lower confidence interval boundaries > 1.0. Associations were stronger among women with ≥ 3 sexual partners (vs. 0) by age 17. Discussion: We found longitudinally assessed associations between OC use, sexual intercourse, and number of sexual partners during adolescence and LUTS at age 19.

AB - Purpose: We examined how antecedent sexual health factors affect lower urinary tract symptoms (LUTS) in adolescent women. Methods: We analyzed 1,941 adolescent women from the Avon Longitudinal Study of Parents and Children at age 19. At ages 15 and 17, participants reported use of oral contraceptives (OCs), history of sexual intercourse, number of sexual partners, and condom use. At age 19, The Bristol Female Lower Urinary Tract Symptoms questionnaire quantified the frequency over the past month: stress incontinence, any incontinence, urgency, sensation of incomplete emptying, bladder pain, and urinary tract infection. Multivariable regression models examined associations between sexual health behaviors reported at ages 15 and 17 and six LUTS reported at age 19, after controlling for covariates. Results: Commonly reported LUTS at age 19 were past-month stress incontinence (26.8%), bladder pain (26.3%), any urine leakage (22.1%), and urinary tract infection (15.4%). OC use by age 17 was associated with urgency (odds ratio [OR] = 1.62, 95% confidence interval [CI] 1.19–2.20), incomplete emptying (OR = 1.62, 95% CI = 1.17–2.26), bladder pain (OR = 1.45, 95% CI = 1.15–1.83), and urinary tract infections (OR = 1.68, 95% CI = 1.28–2.21) at age 19 after adjustment for covariates. However, associations were attenuated after adjustment for condom use and number of sexual partners. Sexual intercourse by age 17 was associated with 1.53–2.65 increased odds of LUTs categories except incontinence, with lower confidence interval boundaries > 1.0. Associations were stronger among women with ≥ 3 sexual partners (vs. 0) by age 17. Discussion: We found longitudinally assessed associations between OC use, sexual intercourse, and number of sexual partners during adolescence and LUTS at age 19.

KW - ALSPAC

KW - Adolescent women

KW - Epidemiology

KW - Lower urinary tract symptoms

KW - Sexual history

UR - http://www.scopus.com/inward/record.url?scp=85150467690&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85150467690&partnerID=8YFLogxK

U2 - 10.1016/j.jadohealth.2022.12.019

DO - 10.1016/j.jadohealth.2022.12.019

M3 - Article

C2 - 36781327

AN - SCOPUS:85150467690

SN - 1054-139X

VL - 72

SP - 737

EP - 745

JO - Journal of Adolescent Health

JF - Journal of Adolescent Health

IS - 5

ER -

Sexual Health Behaviors by Age 17 and Lower Urinary Tract Symptoms at Age 19: PLUS Research Consortium Analysis of ALSPAC Data

Abstract

Bibliographical note

Keywords

PubMed: MeSH publication types

UN SDGs

Publisher link

Find It

Other files and links

Fingerprint

Cite this