Sex-specific alterations in preterm brain

Amanda Benavides; Andrew Metzger; Alexander Tereshchenko; Amy Conrad; Edward F. Bell; John Spencer; Shannon Ross-Sheehy; Michael Georgieff; Vince Magnotta; Peg Nopoulos

doi:10.1038/s41390-018-0187-5

Sex-specific alterations in preterm brain

Amanda Benavides, Andrew Metzger, Alexander Tereshchenko, Amy Conrad, Edward F. Bell, John Spencer, Shannon Ross-Sheehy, Michael Georgieff, Vince Magnotta, Peg Nopoulos

Neonatology (Pediatrics)

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Background: The literature on brain imaging in premature infants is mostly made up of studies that evaluate neonates, yet the most dynamic time of brain development happens from birth to 1 year of age. This study was designed to obtain quantitative brain measures from magnetic resonance imaging scans of infants born prematurely at 12 months of age. Methods: The subject group was designed to capture a wide range of gestational age (GA) from premature to full-term infants. An age-specific atlas generated quantitative brain measures. A regression model was used to predict effects of GA and sex on brain measures. Results: There was a primary effect of sex on: (1) intracranial volume, males > females; (2) proportional cerebral cortical gray matter (females > males), and (3) cerebral white matter (males > females). GA predicted cerebral volume and cerebral spinal fluid. GA also predicted cortical gray matter in a sex-specific manner with GA having a significant effect on cortical volume in the males, but not in females. Conclusions and relevance: Sex differences in brain structure are large early in life. GA had sex-specific effects highlighting the importance evaluating sex effects in neurodevelopmental outcomes of premature infants.

Original language	English (US)
Pages (from-to)	55-62
Number of pages	8
Journal	Pediatric Research
Volume	85
Issue number	1
DOIs	https://doi.org/10.1038/s41390-018-0187-5
State	Published - Jan 1 2019

Bibliographical note

Funding Information:
We would like to thank all of the families who participated in our study. In addition, we acknowledge Corinne Hamlin, research coordinator for her time and effort. This study was supported by NIH grant 2P01 HL046925, National Institute for Heart, Lung and Blood (NHLBI). Preterm Transfusions: Brain Structure and Function Outcomes. The current study was funded by 2P01 HL046925 (Widness, PI), National Institutes of Heart, Lung and Blood and 1 U54 TR001013 (Rosenthal, PI), and NCATS which funds our Clinical Research Unit.

Publisher Copyright:
© 2018, International Pediatric Research Foundation, Inc.

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10.1038/s41390-018-0187-5

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6353678

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title = "Sex-specific alterations in preterm brain",

abstract = "Background: The literature on brain imaging in premature infants is mostly made up of studies that evaluate neonates, yet the most dynamic time of brain development happens from birth to 1 year of age. This study was designed to obtain quantitative brain measures from magnetic resonance imaging scans of infants born prematurely at 12 months of age. Methods: The subject group was designed to capture a wide range of gestational age (GA) from premature to full-term infants. An age-specific atlas generated quantitative brain measures. A regression model was used to predict effects of GA and sex on brain measures. Results: There was a primary effect of sex on: (1) intracranial volume, males > females; (2) proportional cerebral cortical gray matter (females > males), and (3) cerebral white matter (males > females). GA predicted cerebral volume and cerebral spinal fluid. GA also predicted cortical gray matter in a sex-specific manner with GA having a significant effect on cortical volume in the males, but not in females. Conclusions and relevance: Sex differences in brain structure are large early in life. GA had sex-specific effects highlighting the importance evaluating sex effects in neurodevelopmental outcomes of premature infants.",

author = "Amanda Benavides and Andrew Metzger and Alexander Tereshchenko and Amy Conrad and Bell, {Edward F.} and John Spencer and Shannon Ross-Sheehy and Michael Georgieff and Vince Magnotta and Peg Nopoulos",

note = "Funding Information: We would like to thank all of the families who participated in our study. In addition, we acknowledge Corinne Hamlin, research coordinator for her time and effort. This study was supported by NIH grant 2P01 HL046925, National Institute for Heart, Lung and Blood (NHLBI). Preterm Transfusions: Brain Structure and Function Outcomes. The current study was funded by 2P01 HL046925 (Widness, PI), National Institutes of Heart, Lung and Blood and 1 U54 TR001013 (Rosenthal, PI), and NCATS which funds our Clinical Research Unit. Publisher Copyright: {\textcopyright} 2018, International Pediatric Research Foundation, Inc.",

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doi = "10.1038/s41390-018-0187-5",

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AU - Benavides, Amanda

AU - Metzger, Andrew

AU - Tereshchenko, Alexander

AU - Conrad, Amy

AU - Bell, Edward F.

AU - Spencer, John

AU - Ross-Sheehy, Shannon

AU - Georgieff, Michael

AU - Magnotta, Vince

AU - Nopoulos, Peg

N1 - Funding Information: We would like to thank all of the families who participated in our study. In addition, we acknowledge Corinne Hamlin, research coordinator for her time and effort. This study was supported by NIH grant 2P01 HL046925, National Institute for Heart, Lung and Blood (NHLBI). Preterm Transfusions: Brain Structure and Function Outcomes. The current study was funded by 2P01 HL046925 (Widness, PI), National Institutes of Heart, Lung and Blood and 1 U54 TR001013 (Rosenthal, PI), and NCATS which funds our Clinical Research Unit. Publisher Copyright: © 2018, International Pediatric Research Foundation, Inc.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background: The literature on brain imaging in premature infants is mostly made up of studies that evaluate neonates, yet the most dynamic time of brain development happens from birth to 1 year of age. This study was designed to obtain quantitative brain measures from magnetic resonance imaging scans of infants born prematurely at 12 months of age. Methods: The subject group was designed to capture a wide range of gestational age (GA) from premature to full-term infants. An age-specific atlas generated quantitative brain measures. A regression model was used to predict effects of GA and sex on brain measures. Results: There was a primary effect of sex on: (1) intracranial volume, males > females; (2) proportional cerebral cortical gray matter (females > males), and (3) cerebral white matter (males > females). GA predicted cerebral volume and cerebral spinal fluid. GA also predicted cortical gray matter in a sex-specific manner with GA having a significant effect on cortical volume in the males, but not in females. Conclusions and relevance: Sex differences in brain structure are large early in life. GA had sex-specific effects highlighting the importance evaluating sex effects in neurodevelopmental outcomes of premature infants.

AB - Background: The literature on brain imaging in premature infants is mostly made up of studies that evaluate neonates, yet the most dynamic time of brain development happens from birth to 1 year of age. This study was designed to obtain quantitative brain measures from magnetic resonance imaging scans of infants born prematurely at 12 months of age. Methods: The subject group was designed to capture a wide range of gestational age (GA) from premature to full-term infants. An age-specific atlas generated quantitative brain measures. A regression model was used to predict effects of GA and sex on brain measures. Results: There was a primary effect of sex on: (1) intracranial volume, males > females; (2) proportional cerebral cortical gray matter (females > males), and (3) cerebral white matter (males > females). GA predicted cerebral volume and cerebral spinal fluid. GA also predicted cortical gray matter in a sex-specific manner with GA having a significant effect on cortical volume in the males, but not in females. Conclusions and relevance: Sex differences in brain structure are large early in life. GA had sex-specific effects highlighting the importance evaluating sex effects in neurodevelopmental outcomes of premature infants.

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Sex-specific alterations in preterm brain

Abstract

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