Sex-specific alterations in preterm brain

Amanda Benavides, Andrew Metzger, Alexander Tereshchenko, Amy Conrad, Edward F. Bell, John Spencer, Shannon Ross-Sheehy, Michael Georgieff, Vince Magnotta, Peg Nopoulos

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: The literature on brain imaging in premature infants is mostly made up of studies that evaluate neonates, yet the most dynamic time of brain development happens from birth to 1 year of age. This study was designed to obtain quantitative brain measures from magnetic resonance imaging scans of infants born prematurely at 12 months of age. Methods: The subject group was designed to capture a wide range of gestational age (GA) from premature to full-term infants. An age-specific atlas generated quantitative brain measures. A regression model was used to predict effects of GA and sex on brain measures. Results: There was a primary effect of sex on: (1) intracranial volume, males > females; (2) proportional cerebral cortical gray matter (females > males), and (3) cerebral white matter (males > females). GA predicted cerebral volume and cerebral spinal fluid. GA also predicted cortical gray matter in a sex-specific manner with GA having a significant effect on cortical volume in the males, but not in females. Conclusions and relevance: Sex differences in brain structure are large early in life. GA had sex-specific effects highlighting the importance evaluating sex effects in neurodevelopmental outcomes of premature infants.

Original languageEnglish (US)
Pages (from-to)55-62
Number of pages8
JournalPediatric Research
Volume85
Issue number1
DOIs
StatePublished - Jan 1 2019

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Gestational Age
Brain
Premature Infants
Atlases
Neuroimaging
Sex Characteristics
Magnetic Resonance Imaging
Parturition
Newborn Infant
Gray Matter

Cite this

Benavides, A., Metzger, A., Tereshchenko, A., Conrad, A., Bell, E. F., Spencer, J., ... Nopoulos, P. (2019). Sex-specific alterations in preterm brain. Pediatric Research, 85(1), 55-62. https://doi.org/10.1038/s41390-018-0187-5

Sex-specific alterations in preterm brain. / Benavides, Amanda; Metzger, Andrew; Tereshchenko, Alexander; Conrad, Amy; Bell, Edward F.; Spencer, John; Ross-Sheehy, Shannon; Georgieff, Michael; Magnotta, Vince; Nopoulos, Peg.

In: Pediatric Research, Vol. 85, No. 1, 01.01.2019, p. 55-62.

Research output: Contribution to journalArticle

Benavides, A, Metzger, A, Tereshchenko, A, Conrad, A, Bell, EF, Spencer, J, Ross-Sheehy, S, Georgieff, M, Magnotta, V & Nopoulos, P 2019, 'Sex-specific alterations in preterm brain', Pediatric Research, vol. 85, no. 1, pp. 55-62. https://doi.org/10.1038/s41390-018-0187-5
Benavides A, Metzger A, Tereshchenko A, Conrad A, Bell EF, Spencer J et al. Sex-specific alterations in preterm brain. Pediatric Research. 2019 Jan 1;85(1):55-62. https://doi.org/10.1038/s41390-018-0187-5
Benavides, Amanda ; Metzger, Andrew ; Tereshchenko, Alexander ; Conrad, Amy ; Bell, Edward F. ; Spencer, John ; Ross-Sheehy, Shannon ; Georgieff, Michael ; Magnotta, Vince ; Nopoulos, Peg. / Sex-specific alterations in preterm brain. In: Pediatric Research. 2019 ; Vol. 85, No. 1. pp. 55-62.
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AB - Background: The literature on brain imaging in premature infants is mostly made up of studies that evaluate neonates, yet the most dynamic time of brain development happens from birth to 1 year of age. This study was designed to obtain quantitative brain measures from magnetic resonance imaging scans of infants born prematurely at 12 months of age. Methods: The subject group was designed to capture a wide range of gestational age (GA) from premature to full-term infants. An age-specific atlas generated quantitative brain measures. A regression model was used to predict effects of GA and sex on brain measures. Results: There was a primary effect of sex on: (1) intracranial volume, males > females; (2) proportional cerebral cortical gray matter (females > males), and (3) cerebral white matter (males > females). GA predicted cerebral volume and cerebral spinal fluid. GA also predicted cortical gray matter in a sex-specific manner with GA having a significant effect on cortical volume in the males, but not in females. Conclusions and relevance: Sex differences in brain structure are large early in life. GA had sex-specific effects highlighting the importance evaluating sex effects in neurodevelopmental outcomes of premature infants.

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