Abstract
Background: The literature on brain imaging in premature infants is mostly made up of studies that evaluate neonates, yet the most dynamic time of brain development happens from birth to 1 year of age. This study was designed to obtain quantitative brain measures from magnetic resonance imaging scans of infants born prematurely at 12 months of age. Methods: The subject group was designed to capture a wide range of gestational age (GA) from premature to full-term infants. An age-specific atlas generated quantitative brain measures. A regression model was used to predict effects of GA and sex on brain measures. Results: There was a primary effect of sex on: (1) intracranial volume, males > females; (2) proportional cerebral cortical gray matter (females > males), and (3) cerebral white matter (males > females). GA predicted cerebral volume and cerebral spinal fluid. GA also predicted cortical gray matter in a sex-specific manner with GA having a significant effect on cortical volume in the males, but not in females. Conclusions and relevance: Sex differences in brain structure are large early in life. GA had sex-specific effects highlighting the importance evaluating sex effects in neurodevelopmental outcomes of premature infants.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 55-62 |
| Number of pages | 8 |
| Journal | Pediatric Research |
| Volume | 85 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 2019 |
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PubMed: MeSH publication types
- Journal Article
- Research Support, N.I.H., Extramural
Cite this
Sex-specific alterations in preterm brain. / Benavides, Amanda; Metzger, Andrew; Tereshchenko, Alexander; Conrad, Amy; Bell, Edward F.; Spencer, John; Ross-Sheehy, Shannon; Georgieff, Michael K; Magnotta, Vince; Nopoulos, Peg.
In: Pediatric Research, Vol. 85, No. 1, 01.01.2019, p. 55-62.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Sex-specific alterations in preterm brain
AU - Benavides, Amanda
AU - Metzger, Andrew
AU - Tereshchenko, Alexander
AU - Conrad, Amy
AU - Bell, Edward F.
AU - Spencer, John
AU - Ross-Sheehy, Shannon
AU - Georgieff, Michael K
AU - Magnotta, Vince
AU - Nopoulos, Peg
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Background: The literature on brain imaging in premature infants is mostly made up of studies that evaluate neonates, yet the most dynamic time of brain development happens from birth to 1 year of age. This study was designed to obtain quantitative brain measures from magnetic resonance imaging scans of infants born prematurely at 12 months of age. Methods: The subject group was designed to capture a wide range of gestational age (GA) from premature to full-term infants. An age-specific atlas generated quantitative brain measures. A regression model was used to predict effects of GA and sex on brain measures. Results: There was a primary effect of sex on: (1) intracranial volume, males > females; (2) proportional cerebral cortical gray matter (females > males), and (3) cerebral white matter (males > females). GA predicted cerebral volume and cerebral spinal fluid. GA also predicted cortical gray matter in a sex-specific manner with GA having a significant effect on cortical volume in the males, but not in females. Conclusions and relevance: Sex differences in brain structure are large early in life. GA had sex-specific effects highlighting the importance evaluating sex effects in neurodevelopmental outcomes of premature infants.
AB - Background: The literature on brain imaging in premature infants is mostly made up of studies that evaluate neonates, yet the most dynamic time of brain development happens from birth to 1 year of age. This study was designed to obtain quantitative brain measures from magnetic resonance imaging scans of infants born prematurely at 12 months of age. Methods: The subject group was designed to capture a wide range of gestational age (GA) from premature to full-term infants. An age-specific atlas generated quantitative brain measures. A regression model was used to predict effects of GA and sex on brain measures. Results: There was a primary effect of sex on: (1) intracranial volume, males > females; (2) proportional cerebral cortical gray matter (females > males), and (3) cerebral white matter (males > females). GA predicted cerebral volume and cerebral spinal fluid. GA also predicted cortical gray matter in a sex-specific manner with GA having a significant effect on cortical volume in the males, but not in females. Conclusions and relevance: Sex differences in brain structure are large early in life. GA had sex-specific effects highlighting the importance evaluating sex effects in neurodevelopmental outcomes of premature infants.
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UR - http://www.scopus.com/inward/citedby.url?scp=85054379222&partnerID=8YFLogxK
U2 - 10.1038/s41390-018-0187-5
DO - 10.1038/s41390-018-0187-5
M3 - Article
VL - 85
SP - 55
EP - 62
JO - Pediatric Research
JF - Pediatric Research
SN - 0031-3998
IS - 1
ER -