Sex differences in the corpus callosum of patients with schizophrenia

Matthew S. Panizzon, Anne L. Hoff, Thomas E. Nordahl, William S. Kremen, Barbara Reisman, Mary Wieneke, Debra Harris, Chris Goodman, Scott Espinoza, William Liu, Kelvin Lim

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


The corpus callosum (CC) has been of interest in schizophrenia research because of its possible role in reduced lateralization and because of its sexually dimorphic characteristics. The literature has been replete with structural brain studies that have yielded equivocal results because of failure to address sex differences, handedness, and overall reductions in total brain volume (TBV) associated with schizophrenia. We performed midsagittal corpus callosum area MRI measurements on 71 chronically ill patients with schizophrenia (52 males, 19 females) and 67 controls (49 males, 18 females) using a semiautomated analytic technique subdividing the corpus callosum into five segments. Consistent with a meta-analysis [J. Neurol., Neurosurg. Psychiatry 58 (1995) 457], reductions in total CC area (after controlling for TBV and age) were found in schizophrenia patients relative to controls. However, our effect size, though not statistically significant, was -0.33 compared to -0.18 for the meta-analysis, indicating greater reductions in total CC area in our group of patients. Statistical significance was achieved only in male patients versus male controls (effect size=-0.50). The effect size remained the same when only right-handers were included in the analysis; thus, handedness did not account for this result. CC size was not related to psychiatric symptoms nor cognitive functioning in this group of patients.

Original languageEnglish (US)
Pages (from-to)115-122
Number of pages8
JournalSchizophrenia Research
Issue number1-2
StatePublished - Jul 1 2003

Bibliographical note

Funding Information:
This research was supported by the Department of Mental Health, State of California, and MH30854. The authors would like to thank Adolf Pfefferbaum and Edith Sullivan for providing the MRI images.


  • Corpus callosum
  • Schizophrenia
  • Sex differences


Dive into the research topics of 'Sex differences in the corpus callosum of patients with schizophrenia'. Together they form a unique fingerprint.

Cite this