Sex Differences in Resilience and Resistance to Brain Pathology and Dysfunction Moderated by Cerebrovascular Response to Exercise and Genetic Risk for Alzheimer's Disease

Jacqueline A. Palmer, Carolyn S. Kaufman, Eric D. Vidoni, Robyn A. Honea, Jeffrey M. Burns, Sandra A. Billinger

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Sex as a biological variable appears to contribute to the multifactorial etiology of Alzheimer's disease. We tested sex-based interactions between cerebrovascular function and APOE4 genotype on resistance and resilience to brain pathology and cognitive executive dysfunction in cognitively-normal older adults. Female APOE4 carriers had higher amyloid-β deposition yet achieved similar cognitive performance to males and female noncarriers. Further, female APOE4 carriers with robust cerebrovascular responses to exercise possessed lower amyloid-β. These results suggest a unique cognitive resilience and identify cerebrovascular function as a key mechanism for resistance to age-related brain pathology in females with high genetic vulnerability to Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)535-542
Number of pages8
JournalJournal of Alzheimer's Disease
Volume90
Issue number2
DOIs
StatePublished - 2022
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2022 - IOS Press. All rights reserved.

Keywords

  • Aging
  • Apolipoproteins E
  • amyloid
  • cardiovascular system
  • cerebrovascular circulation
  • cognition
  • female
  • hemodynamics
  • ultrasound

Fingerprint

Dive into the research topics of 'Sex Differences in Resilience and Resistance to Brain Pathology and Dysfunction Moderated by Cerebrovascular Response to Exercise and Genetic Risk for Alzheimer's Disease'. Together they form a unique fingerprint.

Cite this