Sex Differences in Animal Models of Opioid Reward

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations


Purpose of Review: This review aims to discuss sex differences observed in preclinical rodent models of opioid reward. Recent Findings: Utilizing a variety of methodological approaches and drug regimens, no clear consensus has emerged regarding the effects of opiates between males and females. This is quite dissimilar to work examining psychostimulants, where female animals reliably exhibit stronger behavioral responses. Summary: With opioid research quickly expanding to determine the neural underpinnings of opioid addiction, further research is essential to determine the conditions wherein sex differences may occur and how they may relate to the human condition.

Original languageEnglish (US)
Pages (from-to)186-194
Number of pages9
JournalCurrent Sexual Health Reports
Issue number3
StatePublished - Sep 2020

Bibliographical note

Funding Information:
The authors would like to thank S. Swanson, A. Chapp, J. Borland, and E. Kim for their assistance with editing the manuscript (University of Minnesota). We would like to thank S. Swanson (University of Minnesota) for his assistance with mouse behavior testing.

Publisher Copyright:
© 2020, Springer Science+Business Media, LLC, part of Springer Nature.


  • Animal models
  • Drug reward
  • Opioid addiction
  • Sex hormones


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