Sex differences at the initiation stage of rat liver carcinogenesis-influence of growth hormone

Dezhong Liao, Inger Porsch-hällström, Jan Ake Gustafsson, Agneta Blanck

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Male and female rats were initiated with a single dose of 3'-methyl-4-dimethylaminoazobenzene (3'MeDAB), N-hydroxy-2-acetylaminofluorene (N-OH-AAF) or aflatoxin B1 (AFB1) and promoted with 2-acetylaminofluorene plus partial hepatectomy (2-AAF/PH). One group of male rats in each experiment received continuous infusion of pituitary growth hormone (GH) for one week prior to initiation to feminize the secretory pattern of GH and hepatic functions. A significantly larger number of foci in male than in female rats was observed after N-OH-AAF and AFB1 initiation. Continuous GH treatment of male rats decreased the number of N-OH-AAF-initiated foci to the level in females, while no effect of GH was observed on AFB1 initiation. Initiation with 3'MeDAB showed no sex differences in number of foci. In conclusion, the present study demonstrates that sex differences occur at the initiation stage and that the secretory pattern of GH is responsible for the dimorphism in initiation with N-OH-AAF, but not with AFB1.

Original languageEnglish (US)
Pages (from-to)2045-2049
Number of pages5
JournalCarcinogenesis
Volume14
Issue number10
DOIs
StatePublished - Oct 1 1993

Fingerprint Dive into the research topics of 'Sex differences at the initiation stage of rat liver carcinogenesis-influence of growth hormone'. Together they form a unique fingerprint.

Cite this