TY - JOUR
T1 - Sex and menstrual cycle differences in the subjective effects from smoked cocaine in humans
AU - Sofuoglu, Mehmet
AU - Dudish-Poulsen, Susan
AU - Nelson, David B
AU - Pentel, Paul R
AU - Hatsukami, Dorothy K
PY - 1999/8
Y1 - 1999/8
N2 - To investigate sex and menstrual cycle effects in response to cocaine administration, data from existing studies were analyzed. First, responses to a single delivery of 0.4 mg/kg smoked cocaine were investigated. Women reported lower ratings for measures of paranoid/suspicious and heart racing/pounding than did men. In addition, women in the luteal phase reported diminished ratings for a measure of feel high than did both women in the follicular phase of the menstrual cycle and men. Second, responses to up to 6 deliveries of 0.4 mg/kg smoked cocaine were investigated. Women, compared with men, had lower ratings on feel high, heart racing/pounding, and feel stimulated. Results suggest that there are significant sex and menstrual phase differences in the subjective effects of cocaine.
AB - To investigate sex and menstrual cycle effects in response to cocaine administration, data from existing studies were analyzed. First, responses to a single delivery of 0.4 mg/kg smoked cocaine were investigated. Women reported lower ratings for measures of paranoid/suspicious and heart racing/pounding than did men. In addition, women in the luteal phase reported diminished ratings for a measure of feel high than did both women in the follicular phase of the menstrual cycle and men. Second, responses to up to 6 deliveries of 0.4 mg/kg smoked cocaine were investigated. Women, compared with men, had lower ratings on feel high, heart racing/pounding, and feel stimulated. Results suggest that there are significant sex and menstrual phase differences in the subjective effects of cocaine.
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U2 - 10.1037/1064-1297.7.3.274
DO - 10.1037/1064-1297.7.3.274
M3 - Article
C2 - 10472516
AN - SCOPUS:0032792818
SN - 1064-1297
VL - 7
SP - 274
EP - 283
JO - Experimental and Clinical Psychopharmacology
JF - Experimental and Clinical Psychopharmacology
IS - 3
ER -