Serum sickness-like drug reaction: two cases with a neutrophilic urticarial pattern

Cuong V. Nguyen, Daniel D. Miller

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


The diagnosis of serum sickness-like reaction (SSLR) is typically based on clinical findings. Histopathologic examination is often deferred, as these eruptions commonly present in young children, and often to primary care providers. A PubMed literature search revealed only five existing cases of SSLR which describe cutaneous histopathologic features. We report two cases of SSLR, one each to bupropion and cefazolin. Skin biopsy findings in both cases showed a neutrophil-predominant urticarial pattern resembling neutrophilic urticaria or neutrophilic urticarial dermatosis. We also provide a summary of the histopathologic findings that can help support a diagnosis of SSLR.

Original languageEnglish (US)
Pages (from-to)177-182
Number of pages6
JournalJournal of cutaneous pathology
Issue number2
StatePublished - Feb 1 2017

Bibliographical note

Publisher Copyright:
© 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd


  • bupropion
  • cefazolin
  • cutaneous drug reaction
  • neutrophilic dermatoses
  • serum sickness-like reaction


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