Serum total sialic acid (S-TSA) is a recently identified risk marker for atherosclerosis and cardiovascular mortality. The purpose of this study was to evaluate the influence of three sialic acid rich glycoproteins (orosomucoid, haptoglobin, and α1-antitrypsin) on the relationship between S-TSA and carotid atherosclerosis. The mean S-TSA was 0.045 g/l higher among cases than controls (P<0.001) in 310 45-64 year-old male and female pairs of carotid atherosclerosis cases and disease-free controls from the Atherosclerosis Risk in Communities (ARIC) Study. Also mean serum levels of the glycoproteins were significantly higher in cases compared to controls. In a conditional multiple logistic regression model with the glycoproteins as independent variables, orosomucoid was correlated most strongly with case control status. However, when incorporated into the mathematical model, S-TSA not only contributed additional information as to the risk of atherosclerosis; none of the three glycoproteins contributed further once S-TSA had been accounted for. Thus, some other source of serum sialic acid or variations in the degree of sialylation of glycoproteins may be essential for understanding the relation between S-TSA and atherosclerosis. Copyright (C) 1999 Elsevier Science Ireland Ltd.
Bibliographical noteFunding Information:
This study was supported by contracts N01-HC-55015, N01-HC-55016, N01-HC-55018, N01-HC-55019, N01-HC-55020, N01-HC-55021 and N01-HC-55022 from the US National Heart, Lung, and Blood Institute, and by the Swedish Heart and Lung Foundation, the Swedish National Public Health Institute, the Swedish Medical Research Council, the Swedish Society of Medicine, the Johan and Henning Throne-Holst Foundation and the Faculty of Medicine, Lund University, Sweden. The authors thank the following ARIC staff: Phyllis Johnson, Marilyn Knowles, Catherine Paton of the University of North Carolina, Chapel Hill; Dawn Scott, Nadine Shelton, Carol Smith, Pamela Williams of the University of North Carolina, Forsyth County; Virginia Overman, Stephanie Parker, Liza Sullivan, Cora Walls of the University of Mississippi Medical Center, Jackson; Caryl DeYoung, Mary Doberstein, Chris Dwight, Greg Feitl of the University of Minnesota, Minneapolis; Dorrie Costa, Patricia Crowley, Tammy Crunkleton, Lilly Downs of the Johns Hopkins University, Baltimore; Valarie Stinson, Pam Pfile, Hogan Pham, Teri Trevino of the University of Texas Medical School, Houston; Wanda R. Alexander, Doris J. Harper, Charles E. Rhodes, Selma M. Soyal of the Methodist Hospital, Atherosclerosis Clinical Laboratory, Houston; Linda Allred, Carolyn Bell, Nancy Bourne, Charlene Kearney-Cash of the Bowman-Gray School of Medicine, Ultrasound Reading Center, Winston-Salem; Robert Matherly, Margaret Misch, Stephen Noga, Joy Rollins of the University of North Carolina, Chapel Hill, Coordinating Center.
- Carotid atherosclerosis
- Cross-sectional study
- Sialic acids