Acyclovir levels to date have been performed on plasma rather than serum samples. To determine if serum was an acceptable specimen, acyclovir levels were measured on simultaneously collected plasma and serum samples by radioimmunoassay. Eighty-two paired samples from 20 patients containing between 0.39 and 115.3 μM acyclovir were studied. Least squares regression, orthogonal regression, and two-way analysis of variance with replication all indicated an acceptably high degree of correlation. We concluded that serum is a suitable specimen for measuring acyclovir levels.
Bibliographical noteFunding Information:
From the Departments of Laboratory Medicine and Pathology, Pediatrics, and Pharmacy Service, University of Minnesota Health Sciences Center, Minneapolis, MN. This study was presented in part at the 24th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy, Washington, D.C., October 1984. This study was supported by NIH Grant 13083 and by grants from the Minnesota Medical Foundation and Burroughs Wellcome Company. Address reprint requests to: Henry H. Balfour, Jr., M.D., Box 437 UMHC, University of Minnesota Health Sciences Center, Minneapolis, MN 55455. Received February 24, 1986; revised and accepted April 18, 1986.