Serum insulin-like growth factor-I (IGF-I) does not correlate positively with isometric strength, fatigue, and quality of life in post-polio syndrome

D. A. Trojan, J. P. Collet, M. N. Pollak, S. Shapiro, B. Jubelt, R. G. Miller, J. C. Agre, T. L. Munsat, D. Hollander, R. Tandan, A. Robinson, L. Finch, T. Ducruet, N. R. Cashman

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Objectives and background: To determine if serum insulin-like growth factor-I (IGF-I) levels are associated with strength, body mass index (BMI), fatigue, or quality of life in post-poliomyelitis syndrome (PPS). PPS is likely due to a distal disintegration of enlarged post-polio motor units as a result of terminal axonal sprouting. Age-related decline in growth hormone and IGF-I (which support terminal axonal sprouts) is proposed as a contributing factor. Methods: As part of the North American Post-Poliomyelitis Pyridostigmine Study (NAPPS), baseline data on maximum voluntary isometric contraction (MVIC), BMI, subjective fatigue (fatigue severity scale, Hare fatigue symptom scale), health-related quality of life (short form health survey-36; SF-36), and serum IGF-I levels were gathered on 112 PPS patients. Pearson correlation coefficients were calculated to evaluate the association between serum IGF-I and MVIC in 12 muscles, BMI, two fatigue scales, and SF-36 scale scores. Results: There is a significant inverse correlation of IGF-I levels with MVIC in left ankle dorsiflexors (r = -0.30, P<0.01), and left and right knee extensors (r = -0.22, -0.25, P = <0.01, 0.01), but no significant correlations in other muscles. When men and women were evaluated separately, inverse correlations of IGF-I levels with MVIC were found only in men. IGF-I correlated inversely with BMI (r = -0.32, P = 0006) and age (r = -0.32, P = 0.0005). IGF-I did not correlate with the fatigue or SF-36 scales. Conclusions: In this exploratory study, we found that contrary to our expectations, IGF-I did not correlate positively with strength. IGF-I correlated negatively with strength in several lower extremity muscles, BMI, and age. IGF-I is likely not an important factor in the pathogenesis of fatigue and in determining quality of life in PPS, but its role on strength should be studied further.

Original languageEnglish (US)
Pages (from-to)107-115
Number of pages9
JournalJournal of the Neurological Sciences
Issue number2
StatePublished - Jan 1 2001



  • Body mass index
  • Fatigue
  • Insulin-like growth factor-I
  • Poliomyelitis
  • Quality of life
  • Strength

Cite this

Trojan, D. A., Collet, J. P., Pollak, M. N., Shapiro, S., Jubelt, B., Miller, R. G., Agre, J. C., Munsat, T. L., Hollander, D., Tandan, R., Robinson, A., Finch, L., Ducruet, T., & Cashman, N. R. (2001). Serum insulin-like growth factor-I (IGF-I) does not correlate positively with isometric strength, fatigue, and quality of life in post-polio syndrome. Journal of the Neurological Sciences, 182(2), 107-115.