Serum inhibin-b in fertile men is strongly correlated with low but not high sperm counts

A coordinated study of 1,797 European and US men

Niels Jørgensen, Fan Liu, Anna Maria Andersson, Matti Vierula, D. Stewart Irvine, Jacques Auger, Charlene K. Brazil, Erma Z. Drobnis, Tina K. Jensen, Pierre Jouannet, James W. Overstreet, J. Bruce Redmon, Amy Sparks, Jorma Toppari, Christina Wang, Niels E. Skakkebæk, Shanna H. Swan

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Objective: To describe associations between serum inhibin-b and sperm counts, adjusted for effect of time of blood sampling, in larger cohorts than have been previously reported. Design: Cross-sectional studies of spermatogenesis markers. Setting: Four European and four US centers. Patient(s): Fertile men (1,797) were included and examined from October 1996-February 2005. Intervention(s): The study was observational and therefore without any intervention. Main Outcome Measure(s): Associations between inhibin-b and semen variables controlled for time of blood sampling and other covariates. Result(s): Inhibin-b decreased about 2.00% per hour from 8 am-12 pm and then about 3.25% per hour from 12 pm-4 pm. There was a strong positive association between inhibin-b levels less than 150 pg/mL and both sperm concentration and total sperm count (slopes of the regression lines were β = 0.011 and β = 0.013 for natural logarithm-transformed sperm concentration and total sperm count, respectively). For inhibin-b levels of 150-300 pg/mL the associations were not as steep (β = 0.002), but still significant. For inhibin-b levels more than 300 pg/mL there was little association to the sperm counts. Neither sperm motility nor morphology was significantly related to inhibin-b level in any group. Conclusion(s): Serum inhibin-b levels decrease nonlinearly during the daytime, and are positively correlated with sperm counts, but the predictive power is best when inhibin-b is low.

Original languageEnglish (US)
Pages (from-to)2128-2134
Number of pages7
JournalFertility and Sterility
Volume94
Issue number6
DOIs
StatePublished - Nov 1 2010

Fingerprint

Inhibins
Sperm Count
Serum
Spermatozoa
Sperm Motility
Spermatogenesis
Semen
Observational Studies
Cross-Sectional Studies
Outcome Assessment (Health Care)

Keywords

  • Inhibin-b
  • fertile men
  • follicle-stimulating hormone
  • sperm concentration
  • total sperm count

Cite this

Serum inhibin-b in fertile men is strongly correlated with low but not high sperm counts : A coordinated study of 1,797 European and US men. / Jørgensen, Niels; Liu, Fan; Andersson, Anna Maria; Vierula, Matti; Irvine, D. Stewart; Auger, Jacques; Brazil, Charlene K.; Drobnis, Erma Z.; Jensen, Tina K.; Jouannet, Pierre; Overstreet, James W.; Redmon, J. Bruce; Sparks, Amy; Toppari, Jorma; Wang, Christina; Skakkebæk, Niels E.; Swan, Shanna H.

In: Fertility and Sterility, Vol. 94, No. 6, 01.11.2010, p. 2128-2134.

Research output: Contribution to journalArticle

Jørgensen, N, Liu, F, Andersson, AM, Vierula, M, Irvine, DS, Auger, J, Brazil, CK, Drobnis, EZ, Jensen, TK, Jouannet, P, Overstreet, JW, Redmon, JB, Sparks, A, Toppari, J, Wang, C, Skakkebæk, NE & Swan, SH 2010, 'Serum inhibin-b in fertile men is strongly correlated with low but not high sperm counts: A coordinated study of 1,797 European and US men', Fertility and Sterility, vol. 94, no. 6, pp. 2128-2134. https://doi.org/10.1016/j.fertnstert.2009.12.051
Jørgensen, Niels ; Liu, Fan ; Andersson, Anna Maria ; Vierula, Matti ; Irvine, D. Stewart ; Auger, Jacques ; Brazil, Charlene K. ; Drobnis, Erma Z. ; Jensen, Tina K. ; Jouannet, Pierre ; Overstreet, James W. ; Redmon, J. Bruce ; Sparks, Amy ; Toppari, Jorma ; Wang, Christina ; Skakkebæk, Niels E. ; Swan, Shanna H. / Serum inhibin-b in fertile men is strongly correlated with low but not high sperm counts : A coordinated study of 1,797 European and US men. In: Fertility and Sterility. 2010 ; Vol. 94, No. 6. pp. 2128-2134.
@article{8a2f982b716d4c538ddc6019a18b116e,
title = "Serum inhibin-b in fertile men is strongly correlated with low but not high sperm counts: A coordinated study of 1,797 European and US men",
abstract = "Objective: To describe associations between serum inhibin-b and sperm counts, adjusted for effect of time of blood sampling, in larger cohorts than have been previously reported. Design: Cross-sectional studies of spermatogenesis markers. Setting: Four European and four US centers. Patient(s): Fertile men (1,797) were included and examined from October 1996-February 2005. Intervention(s): The study was observational and therefore without any intervention. Main Outcome Measure(s): Associations between inhibin-b and semen variables controlled for time of blood sampling and other covariates. Result(s): Inhibin-b decreased about 2.00{\%} per hour from 8 am-12 pm and then about 3.25{\%} per hour from 12 pm-4 pm. There was a strong positive association between inhibin-b levels less than 150 pg/mL and both sperm concentration and total sperm count (slopes of the regression lines were β = 0.011 and β = 0.013 for natural logarithm-transformed sperm concentration and total sperm count, respectively). For inhibin-b levels of 150-300 pg/mL the associations were not as steep (β = 0.002), but still significant. For inhibin-b levels more than 300 pg/mL there was little association to the sperm counts. Neither sperm motility nor morphology was significantly related to inhibin-b level in any group. Conclusion(s): Serum inhibin-b levels decrease nonlinearly during the daytime, and are positively correlated with sperm counts, but the predictive power is best when inhibin-b is low.",
keywords = "Inhibin-b, fertile men, follicle-stimulating hormone, sperm concentration, total sperm count",
author = "Niels J{\o}rgensen and Fan Liu and Andersson, {Anna Maria} and Matti Vierula and Irvine, {D. Stewart} and Jacques Auger and Brazil, {Charlene K.} and Drobnis, {Erma Z.} and Jensen, {Tina K.} and Pierre Jouannet and Overstreet, {James W.} and Redmon, {J. Bruce} and Amy Sparks and Jorma Toppari and Christina Wang and Skakkeb{\ae}k, {Niels E.} and Swan, {Shanna H.}",
year = "2010",
month = "11",
day = "1",
doi = "10.1016/j.fertnstert.2009.12.051",
language = "English (US)",
volume = "94",
pages = "2128--2134",
journal = "Fertility and Sterility",
issn = "0015-0282",
publisher = "Elsevier Inc.",
number = "6",

}

TY - JOUR

T1 - Serum inhibin-b in fertile men is strongly correlated with low but not high sperm counts

T2 - A coordinated study of 1,797 European and US men

AU - Jørgensen, Niels

AU - Liu, Fan

AU - Andersson, Anna Maria

AU - Vierula, Matti

AU - Irvine, D. Stewart

AU - Auger, Jacques

AU - Brazil, Charlene K.

AU - Drobnis, Erma Z.

AU - Jensen, Tina K.

AU - Jouannet, Pierre

AU - Overstreet, James W.

AU - Redmon, J. Bruce

AU - Sparks, Amy

AU - Toppari, Jorma

AU - Wang, Christina

AU - Skakkebæk, Niels E.

AU - Swan, Shanna H.

PY - 2010/11/1

Y1 - 2010/11/1

N2 - Objective: To describe associations between serum inhibin-b and sperm counts, adjusted for effect of time of blood sampling, in larger cohorts than have been previously reported. Design: Cross-sectional studies of spermatogenesis markers. Setting: Four European and four US centers. Patient(s): Fertile men (1,797) were included and examined from October 1996-February 2005. Intervention(s): The study was observational and therefore without any intervention. Main Outcome Measure(s): Associations between inhibin-b and semen variables controlled for time of blood sampling and other covariates. Result(s): Inhibin-b decreased about 2.00% per hour from 8 am-12 pm and then about 3.25% per hour from 12 pm-4 pm. There was a strong positive association between inhibin-b levels less than 150 pg/mL and both sperm concentration and total sperm count (slopes of the regression lines were β = 0.011 and β = 0.013 for natural logarithm-transformed sperm concentration and total sperm count, respectively). For inhibin-b levels of 150-300 pg/mL the associations were not as steep (β = 0.002), but still significant. For inhibin-b levels more than 300 pg/mL there was little association to the sperm counts. Neither sperm motility nor morphology was significantly related to inhibin-b level in any group. Conclusion(s): Serum inhibin-b levels decrease nonlinearly during the daytime, and are positively correlated with sperm counts, but the predictive power is best when inhibin-b is low.

AB - Objective: To describe associations between serum inhibin-b and sperm counts, adjusted for effect of time of blood sampling, in larger cohorts than have been previously reported. Design: Cross-sectional studies of spermatogenesis markers. Setting: Four European and four US centers. Patient(s): Fertile men (1,797) were included and examined from October 1996-February 2005. Intervention(s): The study was observational and therefore without any intervention. Main Outcome Measure(s): Associations between inhibin-b and semen variables controlled for time of blood sampling and other covariates. Result(s): Inhibin-b decreased about 2.00% per hour from 8 am-12 pm and then about 3.25% per hour from 12 pm-4 pm. There was a strong positive association between inhibin-b levels less than 150 pg/mL and both sperm concentration and total sperm count (slopes of the regression lines were β = 0.011 and β = 0.013 for natural logarithm-transformed sperm concentration and total sperm count, respectively). For inhibin-b levels of 150-300 pg/mL the associations were not as steep (β = 0.002), but still significant. For inhibin-b levels more than 300 pg/mL there was little association to the sperm counts. Neither sperm motility nor morphology was significantly related to inhibin-b level in any group. Conclusion(s): Serum inhibin-b levels decrease nonlinearly during the daytime, and are positively correlated with sperm counts, but the predictive power is best when inhibin-b is low.

KW - Inhibin-b

KW - fertile men

KW - follicle-stimulating hormone

KW - sperm concentration

KW - total sperm count

UR - http://www.scopus.com/inward/record.url?scp=78049281395&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78049281395&partnerID=8YFLogxK

U2 - 10.1016/j.fertnstert.2009.12.051

DO - 10.1016/j.fertnstert.2009.12.051

M3 - Article

VL - 94

SP - 2128

EP - 2134

JO - Fertility and Sterility

JF - Fertility and Sterility

SN - 0015-0282

IS - 6

ER -