Serum IGF1, IGF2 and IGFBP3 and risk of advanced colorectal adenoma

Ying Gao, Hormuzd Katki, Barry Graubard, Michael Pollak, Michael Martin, Yuzhen Tao, Robert E. Schoen, Timothy Church, Richard B. Hayes, Mark H. Greene, Sonja I. Berndt

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

The insulin-like growth factor (IGF) signaling pathway is involved in cell proliferation and differentiation. Elevated serum IGF1 levels have been associated with increased colorectal cancer risk; however, studies of this association with colorectal adenoma are inconclusive. We examined serum IGF1, IGF2 and IGFBP3 levels in relation to risk of advanced colorectal adenoma in a case-control study within the prostate, lung, colorectal and ovarian cancer screening trial. A total of 764 advanced, left-sided colorectal adenoma cases and 775 controls frequency-matched on gender and ethnicity, without evidence of a left-sided polyp on sigmoidoscopy were included in the current study. Serum levels of IGF1, IGF2 and IGFBP3 were measured using an enzyme linked immunosorbent assay in serum samples collected at baseline. Logistic regression was used to estimate the odds ratios (OR) and 95% confidence intervals (CI) for the associations adjusting for age, race, sex, year of blood draw, body mass index, smoking and education. Higher IGF1 levels were associated with increased adenoma risk: ORs = 1.58 (95% CI = 1.16-2.16), 1.42 (95% CI = 1.04-1.93), and 1.80 (95% CI = 1.30-2.47) for the second, third and fourth quartiles, respectively (p trend = 0.002). Elevated IGF2 levels were also associated with increased adenoma risk (OR = 1.43, 95% CI = 1.05-1.96 for the fourth vs. first quartile, p trend = 0.02), but the association was no longer significant after adjustment for IGF1 (p trend = 0.28). IGFBP3 levels were not associated with adenoma risk. Our analysis showed a significant positive association between circulating IGF1 levels and risk of advanced colorectal adenoma, suggesting that IGF1 is associated with the pivotal precursor to colorectal cancer.

Original languageEnglish (US)
Pages (from-to)E105-E113
JournalInternational Journal of Cancer
Volume131
Issue number2
DOIs
StatePublished - Jul 15 2012

Keywords

  • colorectal adenoma
  • insulin-like growth factor

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