TY - JOUR
T1 - Serum hepatocyte growth factor and cancer mortality in an apparently healthy Japanese population
AU - Otsuka, Maki
AU - Adachi, Hisashi
AU - Jacobs, David R.
AU - Hirai, Yuji
AU - Enomoto, Mika
AU - Fukami, Ako
AU - Kumagae, Shun Ichi
AU - Nanjo, Yasuki
AU - Yoshikawa, Kuniko
AU - Esaki, Eishi
AU - Kumagai, Eita
AU - Yokoi, Kanako
AU - Ogata, Kinuka
AU - Tsukagawa, Eri
AU - Kasahara, Akiko
AU - Ohbu, Kyoko
AU - Imaizumi, Tsutomu
PY - 2012
Y1 - 2012
N2 - Background: In patients with cancer, hepatocyte growth factor (HGF) is elevated and is a predictor of prognosis. We investigated whether serum HGF was a predictive marker for cancer death in a population of communitydwelling Japanese. Methods: We studied 1492 apparently healthy Japanese adults who underwent health examinations in 1999. Those who reported a history of liver disease or malignancy on a baseline questionnaire were excluded, and plasma HGF was measured in the remaining 1470 participants, who were followed periodically for 10 years. Multivariate proportional hazards regression was used to estimate cancer mortality. Results: A total of 169 participants died during follow-up (61 from cancer, 32 from cerebrocardiovascular disease, and 76 from other diseases). Mean HGF at baseline was significantly higher among decedents than among survivors (0.26 ± 0.11 vs 0.23 ± 0.09 ng/ml, respectively; P < 0.01). The Cox proportional hazards model showed that age, systolic blood pressure, HGF (hazard ratio, 1.27; 95% CI, 1.06-1.52; P = 0.009), albumin level, smoking status, and creatinine were independent predictors of all-cause death. Age, HGF (hazard ratio, 1.31; 95% CI, 1.04-1.65; P = 0.02), and total cholesterol were independent predictive markers for cancer death. Conclusions: Serum HGF was a predictor of cancer death in an apparently healthy population of communitydwelling Japanese.
AB - Background: In patients with cancer, hepatocyte growth factor (HGF) is elevated and is a predictor of prognosis. We investigated whether serum HGF was a predictive marker for cancer death in a population of communitydwelling Japanese. Methods: We studied 1492 apparently healthy Japanese adults who underwent health examinations in 1999. Those who reported a history of liver disease or malignancy on a baseline questionnaire were excluded, and plasma HGF was measured in the remaining 1470 participants, who were followed periodically for 10 years. Multivariate proportional hazards regression was used to estimate cancer mortality. Results: A total of 169 participants died during follow-up (61 from cancer, 32 from cerebrocardiovascular disease, and 76 from other diseases). Mean HGF at baseline was significantly higher among decedents than among survivors (0.26 ± 0.11 vs 0.23 ± 0.09 ng/ml, respectively; P < 0.01). The Cox proportional hazards model showed that age, systolic blood pressure, HGF (hazard ratio, 1.27; 95% CI, 1.06-1.52; P = 0.009), albumin level, smoking status, and creatinine were independent predictors of all-cause death. Age, HGF (hazard ratio, 1.31; 95% CI, 1.04-1.65; P = 0.02), and total cholesterol were independent predictive markers for cancer death. Conclusions: Serum HGF was a predictor of cancer death in an apparently healthy population of communitydwelling Japanese.
KW - Cancer
KW - Cytokine
KW - Mortality
KW - Prospective study
KW - Seven countries study
UR - http://www.scopus.com/inward/record.url?scp=84864661734&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84864661734&partnerID=8YFLogxK
U2 - 10.2188/jea.JE20110121
DO - 10.2188/jea.JE20110121
M3 - Article
C2 - 22672958
AN - SCOPUS:84864661734
SN - 0917-5040
VL - 22
SP - 395
EP - 401
JO - Journal of Epidemiology
JF - Journal of Epidemiology
IS - 5
ER -