Serum hepatocyte growth factor and cancer mortality in an apparently healthy Japanese population

Maki Otsuka, Hisashi Adachi, David R. Jacobs, Yuji Hirai, Mika Enomoto, Ako Fukami, Shun Ichi Kumagae, Yasuki Nanjo, Kuniko Yoshikawa, Eishi Esaki, Eita Kumagai, Kanako Yokoi, Kinuka Ogata, Eri Tsukagawa, Akiko Kasahara, Kyoko Ohbu, Tsutomu Imaizumi

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Background: In patients with cancer, hepatocyte growth factor (HGF) is elevated and is a predictor of prognosis. We investigated whether serum HGF was a predictive marker for cancer death in a population of communitydwelling Japanese. Methods: We studied 1492 apparently healthy Japanese adults who underwent health examinations in 1999. Those who reported a history of liver disease or malignancy on a baseline questionnaire were excluded, and plasma HGF was measured in the remaining 1470 participants, who were followed periodically for 10 years. Multivariate proportional hazards regression was used to estimate cancer mortality. Results: A total of 169 participants died during follow-up (61 from cancer, 32 from cerebrocardiovascular disease, and 76 from other diseases). Mean HGF at baseline was significantly higher among decedents than among survivors (0.26 ± 0.11 vs 0.23 ± 0.09 ng/ml, respectively; P < 0.01). The Cox proportional hazards model showed that age, systolic blood pressure, HGF (hazard ratio, 1.27; 95% CI, 1.06-1.52; P = 0.009), albumin level, smoking status, and creatinine were independent predictors of all-cause death. Age, HGF (hazard ratio, 1.31; 95% CI, 1.04-1.65; P = 0.02), and total cholesterol were independent predictive markers for cancer death. Conclusions: Serum HGF was a predictor of cancer death in an apparently healthy population of communitydwelling Japanese.

Original languageEnglish (US)
Pages (from-to)395-401
Number of pages7
JournalJournal of Epidemiology
Volume22
Issue number5
DOIs
StatePublished - 2012

Keywords

  • Cancer
  • Cytokine
  • Mortality
  • Prospective study
  • Seven countries study

Fingerprint Dive into the research topics of 'Serum hepatocyte growth factor and cancer mortality in an apparently healthy Japanese population'. Together they form a unique fingerprint.

Cite this