Serum From Schizophrenic Patients: Effect on Cellular Lactate Stimulation and Tryptophan Uptake

Susan Nicol; Ulysses S. Seal; Irving I Gottesman

doi:10.1001/archpsyc.1973.04200060030004

Serum From Schizophrenic Patients: Effect on Cellular Lactate Stimulation and Tryptophan Uptake

Susan Nicol, Ulysses S. Seal, Irving I Gottesman

Psychiatry & Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

The activity on human serum-chicken red blood cell (RBC) bioassays, which have been reported to measure an abnormal lipoprotein in the serum of some schizophrenics, is not associated with low-density serum lipoproteins upon serum fractionation, but is complement-dependent and can be eliminated from at least some samples by passage through antihuman IgM affinity chromatography columns. Sera with high bioassay activity can be produced by immunizing rabbits with chicken RBCs and there is a strong correlation between hemolysis and bioassay activity (lactate stimulation and tryptophan uptake). It is concluded that hemolysins present in human sera produce high scores on the bioassays. High bioassay activity was not correlated with the diagnosis of schizophrenia among psychiatric patients at the Minneapolis Veterans Administration Hospital.

Original language	English (US)
Pages (from-to)	744-751
Number of pages	8
Journal	Archives of General Psychiatry
Volume	29
Issue number	6
DOIs	https://doi.org/10.1001/archpsyc.1973.04200060030004
State	Published - Dec 1973

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abstract = "The activity on human serum-chicken red blood cell (RBC) bioassays, which have been reported to measure an abnormal lipoprotein in the serum of some schizophrenics, is not associated with low-density serum lipoproteins upon serum fractionation, but is complement-dependent and can be eliminated from at least some samples by passage through antihuman IgM affinity chromatography columns. Sera with high bioassay activity can be produced by immunizing rabbits with chicken RBCs and there is a strong correlation between hemolysis and bioassay activity (lactate stimulation and tryptophan uptake). It is concluded that hemolysins present in human sera produce high scores on the bioassays. High bioassay activity was not correlated with the diagnosis of schizophrenia among psychiatric patients at the Minneapolis Veterans Administration Hospital.",

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AU - Gottesman, Irving I

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Serum From Schizophrenic Patients: Effect on Cellular Lactate Stimulation and Tryptophan Uptake

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