Abstract
Aims We compared cystatin C in youth with versus without diabetes and determined factors associated with cystatin C in youth with type 1 diabetes (T1D) and type 2 diabetes (T2D). Methods Youth (ages 12–19 years) without diabetes (N = 544) were ascertained from the NHANES Study 2000–2002 and those with T1D (N = 977) and T2D (N = 168) from the SEARCH for Diabetes in Youth Study. Adjusted means of cystatin C concentrations were compared amongst the 3 groups. Next, we performed multivariable analyses within the T1D and T2D SEARCH samples to determine the association between cystatin C and race, sex, age, diabetes duration, HbA1c, fasting glucose, and BMI. Results Adjusted cystatin C concentrations were statistically higher in NHANES (0.85 mg/L) than in either the T1D (0.75 mg/L) or T2D (0.70 mg/L) SEARCH groups (P < 0.0001). Fasting glucose was inversely related to cystatin C only in T1D (P < 0.001) and BMI positively associated only in T2D (P < 0.01) while HbA1c was inversely associated in both groups. Conclusions Cystatin C concentrations are statistically higher in youth without diabetes compared to T1D or T2D, however the clinical relevance of this difference is quite small, especially in T1D. In youth with diabetes, cystatin C varies with BMI and acute and chronic glycemic control, however their effects may be different according to diabetes type.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 258-265 |
| Number of pages | 8 |
| Journal | Diabetes Research and Clinical Practice |
| Volume | 130 |
| DOIs | |
| State | Published - Aug 1 2017 |
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Keywords
- Cystatin C
- Type 1 diabetes
- Type 2 diabetes
- Youth
Cite this
Serum cystatin C in youth with diabetes : The SEARCH for diabetes in youth study. / Kanakatti Shankar, Roopa; Dolan, Lawrence M.; Isom, Scott; Saydah, Sharon; Maahs, David M.; Dabelea, Dana; Reynolds, Kristi; Hirsch, Irl B.; Rodriguez, Beatriz L.; Mayer-Davis, Elizabeth J.; Marcovina, Santica; D'Agostino, Ralph; Mauer, Michael; Mottl, Amy K.
In: Diabetes Research and Clinical Practice, Vol. 130, 01.08.2017, p. 258-265.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Serum cystatin C in youth with diabetes
T2 - The SEARCH for diabetes in youth study
AU - Kanakatti Shankar, Roopa
AU - Dolan, Lawrence M.
AU - Isom, Scott
AU - Saydah, Sharon
AU - Maahs, David M.
AU - Dabelea, Dana
AU - Reynolds, Kristi
AU - Hirsch, Irl B.
AU - Rodriguez, Beatriz L.
AU - Mayer-Davis, Elizabeth J.
AU - Marcovina, Santica
AU - D'Agostino, Ralph
AU - Mauer, Michael
AU - Mottl, Amy K.
PY - 2017/8/1
Y1 - 2017/8/1
N2 - Aims We compared cystatin C in youth with versus without diabetes and determined factors associated with cystatin C in youth with type 1 diabetes (T1D) and type 2 diabetes (T2D). Methods Youth (ages 12–19 years) without diabetes (N = 544) were ascertained from the NHANES Study 2000–2002 and those with T1D (N = 977) and T2D (N = 168) from the SEARCH for Diabetes in Youth Study. Adjusted means of cystatin C concentrations were compared amongst the 3 groups. Next, we performed multivariable analyses within the T1D and T2D SEARCH samples to determine the association between cystatin C and race, sex, age, diabetes duration, HbA1c, fasting glucose, and BMI. Results Adjusted cystatin C concentrations were statistically higher in NHANES (0.85 mg/L) than in either the T1D (0.75 mg/L) or T2D (0.70 mg/L) SEARCH groups (P < 0.0001). Fasting glucose was inversely related to cystatin C only in T1D (P < 0.001) and BMI positively associated only in T2D (P < 0.01) while HbA1c was inversely associated in both groups. Conclusions Cystatin C concentrations are statistically higher in youth without diabetes compared to T1D or T2D, however the clinical relevance of this difference is quite small, especially in T1D. In youth with diabetes, cystatin C varies with BMI and acute and chronic glycemic control, however their effects may be different according to diabetes type.
AB - Aims We compared cystatin C in youth with versus without diabetes and determined factors associated with cystatin C in youth with type 1 diabetes (T1D) and type 2 diabetes (T2D). Methods Youth (ages 12–19 years) without diabetes (N = 544) were ascertained from the NHANES Study 2000–2002 and those with T1D (N = 977) and T2D (N = 168) from the SEARCH for Diabetes in Youth Study. Adjusted means of cystatin C concentrations were compared amongst the 3 groups. Next, we performed multivariable analyses within the T1D and T2D SEARCH samples to determine the association between cystatin C and race, sex, age, diabetes duration, HbA1c, fasting glucose, and BMI. Results Adjusted cystatin C concentrations were statistically higher in NHANES (0.85 mg/L) than in either the T1D (0.75 mg/L) or T2D (0.70 mg/L) SEARCH groups (P < 0.0001). Fasting glucose was inversely related to cystatin C only in T1D (P < 0.001) and BMI positively associated only in T2D (P < 0.01) while HbA1c was inversely associated in both groups. Conclusions Cystatin C concentrations are statistically higher in youth without diabetes compared to T1D or T2D, however the clinical relevance of this difference is quite small, especially in T1D. In youth with diabetes, cystatin C varies with BMI and acute and chronic glycemic control, however their effects may be different according to diabetes type.
KW - Cystatin C
KW - Type 1 diabetes
KW - Type 2 diabetes
KW - Youth
UR - http://www.scopus.com/inward/record.url?scp=85021212999&partnerID=8YFLogxK
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U2 - 10.1016/j.diabres.2017.06.010
DO - 10.1016/j.diabres.2017.06.010
M3 - Article
VL - 130
SP - 258
EP - 265
JO - Diabetes Research and Clinical Practice
JF - Diabetes Research and Clinical Practice
SN - 0168-8227
ER -