Serum Cholesterol Levels and Stroke Mortality

Glenn M. Chertow; Zheng Ming Chen; Rory Collins; Richard Peto; Wan Xian li; Norton Spritz; Piet C. de Groen; Allen J. Aksamit; Barbara F. Westmoreland; Bruce A. Kottke; Ruud A.f. Krom; Hiroyasu Iso; David R. Jacobs; Deborah Wentworth; James D. Neaton; Jerome D. Cohen

doi:10.1056/NEJM198911093211913

Serum Cholesterol Levels and Stroke Mortality

Glenn M. Chertow, Zheng Ming Chen, Rory Collins, Richard Peto, Wan Xian li, Norton Spritz, Piet C. de Groen, Allen J. Aksamit, Barbara F. Westmoreland, Bruce A. Kottke, Ruud A.f. Krom, Hiroyasu Iso, David R. Jacobs, Deborah Wentworth, James D. Neaton, Jerome D. Cohen

Research output: Contribution to journal › Letter › peer-review

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Abstract

To the Editor: In the study by Iso et al. (April 6 issue),* I am concerned that the total serum cholesterol rather than fractionated samples were used. Although the data demonstrating increased adjusted relative risk are impressive (a threefold increase), the numbers are small: 11 deaths in the intracranial group and 5 in the subarachnoid group. Might not these 11 patients (0.003 percent of the total) be examples of persons with a low-density lipoprotein (LDL) fraction in the normal or low-normal range, but with unusually low high-density lipoprotein (HDL) fractions?

Original language	English (US)
Pages (from-to)	1339-1341
Number of pages	3
Journal	New England Journal of Medicine
Volume	321
Issue number	19
DOIs	https://doi.org/10.1056/NEJM198911093211913
State	Published - Nov 9 1989

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Chertow, G. M., Chen, Z. M., Collins, R., Peto, R., li, W. X., Spritz, N., de Groen, P. C., Aksamit, A. J., Westmoreland, B. F., Kottke, B. A., Krom, R. A. F., Iso, H., Jacobs, D. R., Wentworth, D., Neaton, J. D., & Cohen, J. D. (1989). Serum Cholesterol Levels and Stroke Mortality. New England Journal of Medicine, 321(19), 1339-1341. https://doi.org/10.1056/NEJM198911093211913

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title = "Serum Cholesterol Levels and Stroke Mortality",

abstract = "To the Editor: In the study by Iso et al. (April 6 issue),* I am concerned that the total serum cholesterol rather than fractionated samples were used. Although the data demonstrating increased adjusted relative risk are impressive (a threefold increase), the numbers are small: 11 deaths in the intracranial group and 5 in the subarachnoid group. Might not these 11 patients (0.003 percent of the total) be examples of persons with a low-density lipoprotein (LDL) fraction in the normal or low-normal range, but with unusually low high-density lipoprotein (HDL) fractions?",

author = "Chertow, {Glenn M.} and Chen, {Zheng Ming} and Rory Collins and Richard Peto and li, {Wan Xian} and Norton Spritz and {de Groen}, {Piet C.} and Aksamit, {Allen J.} and Westmoreland, {Barbara F.} and Kottke, {Bruce A.} and Krom, {Ruud A.f.} and Hiroyasu Iso and Jacobs, {David R.} and Deborah Wentworth and Neaton, {James D.} and Cohen, {Jerome D.}",

year = "1989",

month = nov,

day = "9",

doi = "10.1056/NEJM198911093211913",

language = "English (US)",

volume = "321",

pages = "1339--1341",

journal = "New England Journal of Medicine",

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TY - JOUR

T1 - Serum Cholesterol Levels and Stroke Mortality

AU - Chertow, Glenn M.

AU - Chen, Zheng Ming

AU - Collins, Rory

AU - Peto, Richard

AU - li, Wan Xian

AU - Spritz, Norton

AU - de Groen, Piet C.

AU - Aksamit, Allen J.

AU - Westmoreland, Barbara F.

AU - Kottke, Bruce A.

AU - Krom, Ruud A.f.

AU - Iso, Hiroyasu

AU - Jacobs, David R.

AU - Wentworth, Deborah

AU - Neaton, James D.

AU - Cohen, Jerome D.

PY - 1989/11/9

Y1 - 1989/11/9

N2 - To the Editor: In the study by Iso et al. (April 6 issue),* I am concerned that the total serum cholesterol rather than fractionated samples were used. Although the data demonstrating increased adjusted relative risk are impressive (a threefold increase), the numbers are small: 11 deaths in the intracranial group and 5 in the subarachnoid group. Might not these 11 patients (0.003 percent of the total) be examples of persons with a low-density lipoprotein (LDL) fraction in the normal or low-normal range, but with unusually low high-density lipoprotein (HDL) fractions?

AB - To the Editor: In the study by Iso et al. (April 6 issue),* I am concerned that the total serum cholesterol rather than fractionated samples were used. Although the data demonstrating increased adjusted relative risk are impressive (a threefold increase), the numbers are small: 11 deaths in the intracranial group and 5 in the subarachnoid group. Might not these 11 patients (0.003 percent of the total) be examples of persons with a low-density lipoprotein (LDL) fraction in the normal or low-normal range, but with unusually low high-density lipoprotein (HDL) fractions?

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JO - New England Journal of Medicine

JF - New England Journal of Medicine

IS - 19

ER -

Serum Cholesterol Levels and Stroke Mortality

Abstract

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