Serum Cholesterol Levels and Stroke Mortality

Glenn M. Chertow, Zheng Ming Chen, Rory Collins, Richard Peto, Wan Xian li, Norton Spritz, Piet C. de Groen, Allen J. Aksamit, Barbara F. Westmoreland, Bruce A. Kottke, Ruud A.f. Krom, Hiroyasu Iso, David R. Jacobs, Deborah Wentworth, James D. Neaton, Jerome D. Cohen

Research output: Contribution to journalLetterpeer-review

11 Scopus citations


To the Editor: In the study by Iso et al. (April 6 issue),* I am concerned that the total serum cholesterol rather than fractionated samples were used. Although the data demonstrating increased adjusted relative risk are impressive (a threefold increase), the numbers are small: 11 deaths in the intracranial group and 5 in the subarachnoid group. Might not these 11 patients (0.003 percent of the total) be examples of persons with a low-density lipoprotein (LDL) fraction in the normal or low-normal range, but with unusually low high-density lipoprotein (HDL) fractions?

Original languageEnglish (US)
Pages (from-to)1339-1341
Number of pages3
JournalNew England Journal of Medicine
Issue number19
StatePublished - Nov 9 1989


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