Serum cefazolin levels during spinal fusion: Effect of blood loss and duration of surgery

Francisco H. Lopez-Sosa, David Polly, Stephen C. Eppes, Joel D. Klein, Keith H. St. John, David H. Corddry

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Perioperative cefazolin prophylaxis is commonly employed in posterior spinal fusion (PSF) procedures, which are often lengthy and involve significant blood loss. In this study, serum levels of prophylactically administered cefazolin were measured serially during spinal fusion procedures, and the possible relationship of antibiotic concentrations to blood loss and fluid therapy were examined. Serum antibiotic levels, measured at 30-min intervals, declined with a half-life of 90 min, similar to the previously reported experience with normal adult volunteers. There was no relationship between serum half-life and blood loss or fluid replacement. An explanation for these findings is offered, along with recommendations for dosing.

Original languageEnglish (US)
Pages (from-to)296-299
Number of pages4
JournalJournal of Spinal Disorders
Volume6
Issue number4
DOIs
StatePublished - Aug 1993

Keywords

  • Antibiotic
  • Blood loss
  • Cefazolin
  • Cephalosporin
  • Fusion
  • Infection
  • Posterior spinal

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