Abstract
Background Periprosthetic joint infection is the most common cause of readmissions after total joint arthroplasty (TJA). Intrawound vancomycin powder (VP) has reduced infection rates in spine surgery; however, there are no data regarding VP in primary TJA. Methods Thirty-four TJA patients received 2 g of VP intraoperatively to investigate VP's pharmacokinetics. Serum and wound concentrations were measured at multiple intervals over 24 hours after closure. Results All serum concentrations were subtherapeutic (<15μg/mL) and peaked 12 hours after closure (4.7μg/mL; standard deviation [SD], 3.2). Wound concentrations were 922 μg/mL (SD, 523) 3 hours after closure and 207 μg/mL (SD, 317) at 24 hours. VP had a half-life of 7.2 hours (95% confidence interval, 7.0-9.3) in TJA wounds. Conclusions VP produced highly therapeutic intrawound concentrations while yielding low systemic levels in TJA. VP may serve as a safe adjunct in the prevention of periprosthetic joint infection.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 924-928 |
| Number of pages | 5 |
| Journal | Journal of Arthroplasty |
| Volume | 32 |
| Issue number | 3 |
| DOIs | |
| State | Published - Mar 1 2017 |
Keywords
- intrawound vancomycin concentration
- periprosthetic infection
- primary total joint arthroplasty
- prophylactic vancomycin
- serum vancomycin concentration
- topical vancomycin
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