Serum 17β-Estradiol; index of follicular maturation during gonadotropin therapy

Albert D. Notation, George E. Tagatz, Michael W Steffes

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Thirteen patients with hypogonadotropic hypogonadism were treated with human menopausal gonadotropins (hMG) and human chorionic gonadotropin (hCG) to induce ovulation. Daily serum 17β-estradiol (E2) assays were used to monitor the ovarian response to HMG. Apparent ovulation, documented by basal body temperatures, occurred in 41 of 53 hMG-hCG treatment cycles. Thirteen pregnancies occurred in 8 of the 13 patients. One twin pregnancy resulted. The hyperstimulation syndrome did not occur. Our data indicate that an optimal pregnancy rate with a minimum risk of hyperstimulation can be achieved when ovulation is induced 24 hours after the preovulatory serum E2 concentration has reached 500 to 900 pg/ml. Ovulation is induced by administering 10,000 IU and 5000 IU hCG on successive days. In addition, we now routinely give two or three injections of 2500 IU hCG at subsequent 3- to 4-day intervals to support the corpus luteum.

Original languageEnglish (US)
Pages (from-to)204-209
Number of pages6
JournalObstetrics and gynecology
Volume51
Issue number2
StatePublished - Jan 1 1978

Fingerprint

Chorionic Gonadotropin
Ovulation
Gonadotropins
Estradiol
Menotropins
Serum
Twin Pregnancy
Hypogonadism
Corpus Luteum
Pregnancy Rate
Therapeutics
Body Temperature
Pregnancy
Injections

Cite this

Serum 17β-Estradiol; index of follicular maturation during gonadotropin therapy. / Notation, Albert D.; Tagatz, George E.; Steffes, Michael W.

In: Obstetrics and gynecology, Vol. 51, No. 2, 01.01.1978, p. 204-209.

Research output: Contribution to journalArticle

Notation, Albert D. ; Tagatz, George E. ; Steffes, Michael W. / Serum 17β-Estradiol; index of follicular maturation during gonadotropin therapy. In: Obstetrics and gynecology. 1978 ; Vol. 51, No. 2. pp. 204-209.
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