SERS Detection of Ricin B-Chain via N-Acetyl-Galactosamine Glycopolymers

Victoria M. Szlag; Matthew J. Styles; Lindsey R. Madison; Antonio R. Campos; Bharat Wagh; Dustin Sprouse; George C. Schatz; Theresa M. Reineke; Christy L. Haynes

doi:10.1021/acssensors.6b00209

SERS Detection of Ricin B-Chain via N-Acetyl-Galactosamine Glycopolymers

Victoria M. Szlag
, Matthew J. Styles
, Lindsey R. Madison
, Antonio R. Campos
, Bharat Wagh
, Dustin Sprouse
, George C. Schatz
, Theresa M. Reineke
, Christy L. Haynes

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

A novel sensing scheme is exemplified through the detection of ricin B-chain (RBC) in water and liquid food matrices: surface-enhanced Raman spectroscopy (SERS) coupled with an N-acetyl-galactosamine glycopolymer capture layer. The sensing scheme's detection limit was well below that of the predicted oral exposure limit. Theoretical predictions of the normal Raman spectrum of the glycomonomer give insight into polymer-RBC intermolecular interactions.

Original language	English (US)
Pages (from-to)	842-846
Number of pages	5
Journal	ACS Sensors
Volume	1
Issue number	7
DOIs	https://doi.org/10.1021/acssensors.6b00209
State	Published - Jul 22 2016

Bibliographical note

Publisher Copyright:
© 2016 American Chemical Society.

Keywords

DFT modeling
film over nanospheres
glycopolymers
ricin
surface-enhanced raman spectroscopy

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@article{4057c28f483241ea80b05b05f510e259,

title = "SERS Detection of Ricin B-Chain via N-Acetyl-Galactosamine Glycopolymers",

abstract = "A novel sensing scheme is exemplified through the detection of ricin B-chain (RBC) in water and liquid food matrices: surface-enhanced Raman spectroscopy (SERS) coupled with an N-acetyl-galactosamine glycopolymer capture layer. The sensing scheme's detection limit was well below that of the predicted oral exposure limit. Theoretical predictions of the normal Raman spectrum of the glycomonomer give insight into polymer-RBC intermolecular interactions.",

keywords = "DFT modeling, film over nanospheres, glycopolymers, ricin, surface-enhanced raman spectroscopy",

author = "Szlag, \{Victoria M.\} and Styles, \{Matthew J.\} and Madison, \{Lindsey R.\} and Campos, \{Antonio R.\} and Bharat Wagh and Dustin Sprouse and Schatz, \{George C.\} and Reineke, \{Theresa M.\} and Haynes, \{Christy L.\}",

note = "Publisher Copyright: {\textcopyright} 2016 American Chemical Society.",

year = "2016",

month = jul,

day = "22",

doi = "10.1021/acssensors.6b00209",

language = "English (US)",

volume = "1",

pages = "842--846",

journal = "ACS Sensors",

issn = "2379-3694",

publisher = "American Chemical Society",

number = "7",

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TY - JOUR

T1 - SERS Detection of Ricin B-Chain via N-Acetyl-Galactosamine Glycopolymers

AU - Szlag, Victoria M.

AU - Styles, Matthew J.

AU - Madison, Lindsey R.

AU - Campos, Antonio R.

AU - Wagh, Bharat

AU - Sprouse, Dustin

AU - Schatz, George C.

AU - Reineke, Theresa M.

AU - Haynes, Christy L.

PY - 2016/7/22

Y1 - 2016/7/22

N2 - A novel sensing scheme is exemplified through the detection of ricin B-chain (RBC) in water and liquid food matrices: surface-enhanced Raman spectroscopy (SERS) coupled with an N-acetyl-galactosamine glycopolymer capture layer. The sensing scheme's detection limit was well below that of the predicted oral exposure limit. Theoretical predictions of the normal Raman spectrum of the glycomonomer give insight into polymer-RBC intermolecular interactions.

AB - A novel sensing scheme is exemplified through the detection of ricin B-chain (RBC) in water and liquid food matrices: surface-enhanced Raman spectroscopy (SERS) coupled with an N-acetyl-galactosamine glycopolymer capture layer. The sensing scheme's detection limit was well below that of the predicted oral exposure limit. Theoretical predictions of the normal Raman spectrum of the glycomonomer give insight into polymer-RBC intermolecular interactions.

KW - DFT modeling

KW - film over nanospheres

KW - glycopolymers

KW - ricin

KW - surface-enhanced raman spectroscopy

UR - https://www.scopus.com/pages/publications/84994375730

UR - https://www.scopus.com/pages/publications/84994375730#tab=citedBy

U2 - 10.1021/acssensors.6b00209

DO - 10.1021/acssensors.6b00209

M3 - Article

AN - SCOPUS:84994375730

SN - 2379-3694

VL - 1

SP - 842

EP - 846

JO - ACS Sensors

JF - ACS Sensors

IS - 7

ER -

SERS Detection of Ricin B-Chain via N-Acetyl-Galactosamine Glycopolymers

Abstract

Bibliographical note

Keywords

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MRSEC IRG-2: Sustainable Nanocrystal Materials

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SERS Detection of Ricin B-Chain via N-Acetyl-Galactosamine Glycopolymers

Abstract

Bibliographical note

Keywords

MRSEC Support

Publisher link

Find It

Other files and links

Fingerprint

Projects

MRSEC IRG-2: Sustainable Nanocrystal Materials

MRSEC IRG-3: Hierarchical Multifunctional Macromolecular Materials

University of Minnesota MRSEC (DMR-1420013)

Cite this